*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SM6490000
CHEMICAL NAME           : Phenol, pentachloro-, sodium salt
CAS REGISTRY NUMBER     : 131-52-2
LAST UPDATED            : 199801
DATA ITEMS CITED        : 33
MOLECULAR FORMULA       : C6-Cl5-O.Na
MOLECULAR WEIGHT        : 288.30
WISWESSER LINE NOTATION : QR BG CG DG EG FG &-NA-
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Dow dormant fungicide
   * Dowicide G
   * Dowicide G-ST
   * GR 48-11PS
   * GR 48-32S
   * Mystox D
   * Napclor-G
   * Pentachlorophenate sodium
   * Pentachlorophenol, sodium salt
   * Pentachlorophenoxy sodium
   * Pentanot 25
   * Pentaphenate
   * Preventol PN
   * Santobrite
   * Sapco 25
   * Sodium PCP
   * Sodium pentachlorophenol
   * Sodium pentachlorophenolate
   * Sodium pentachlorophenoxide
   * Sodium, (pentachlorophenoxy)-
   * Sodium pentachlorphenate
   * Weedbeads
   * Witophen N
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 126 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHYCDW Zhonghua Yufangyixue Zazhi.  Chinese Journal of Preventive Medicine.
   (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
   China)  Beginning history not known.  Volume(issue)/page/year: 13,8,1979
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11700 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 15,463,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 66 mg/kg
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
   Endocrine - hyperglycemia
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 76,104,1942
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 146 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MZUZA8 Meditsinskii Zhurnal Uzbekistana.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) No.1-    1957-  Volume(issue)/page/year: (9),29,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 197 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,106,1982
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 240 mg/m3/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,106,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 124 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,106,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 63700 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
   Skin and Appendages - hair
REFERENCE :
   OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi.  Journal of the Osaka City
   Medical Center.  (Osaka, Japan)  V.4-23, 1955-74.  For publisher
   information, see OIGZDE.  Volume(issue)/page/year: 5,119,1956
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co.,
   1956-59  Volume(issue)/page/year: 5,125,1959
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 164 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MZUZA8 Meditsinskii Zhurnal Uzbekistana.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) No.1-    1957-  Volume(issue)/page/year: (9),29,1959
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co.,
   1956-59  Volume(issue)/page/year: 5,125,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 328 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MZUZA8 Meditsinskii Zhurnal Uzbekistana.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) No.1-    1957-  Volume(issue)/page/year: (9),29,1959
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
   Endocrine - hyperglycemia
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 76,104,1942
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 23,239,1941
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
   Endocrine - hyperglycemia
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 76,104,1942
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
   Endocrine - hyperglycemia
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 76,104,1942
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MZUZA8 Meditsinskii Zhurnal Uzbekistana.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) No.1-    1957-  Volume(issue)/page/year: (9),29,1959
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 341 mg/m3/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,106,1982
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 266 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co.,
   1956-59  Volume(issue)/page/year: 5,125,1959
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 120 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MZUZA8 Meditsinskii Zhurnal Uzbekistana.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) No.1-    1957-  Volume(issue)/page/year: (9),29,1959
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/m3/13W-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   MZUZA8 Meditsinskii Zhurnal Uzbekistana.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) No.1-    1957-  Volume(issue)/page/year: (9),29,1959
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/m3/13W-I
TOXIC EFFECTS :
   Liver - fatty liver degeneration
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   MZUZA8 Meditsinskii Zhurnal Uzbekistana.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) No.1-    1957-  Volume(issue)/page/year: (9),29,1959
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/m3/13W-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   MZUZA8 Meditsinskii Zhurnal Uzbekistana.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) No.1-    1957-  Volume(issue)/page/year: (9),29,1959
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 500 mg/m3/13W-I
TOXIC EFFECTS :
   Liver - fatty liver degeneration
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   MZUZA8 Meditsinskii Zhurnal Uzbekistana.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) No.1-    1957-  Volume(issue)/page/year: (9),29,1959
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 360 mg/kg
SEX/DURATION            : female 8-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   CHYCDW Zhonghua Yufangyixue Zazhi.  Chinese Journal of Preventive Medicine.
   (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
   China)  Beginning history not known.  Volume(issue)/page/year: 13,8,1979
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 5 ug/disc
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 40,19,1976

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
   FEREAC Federal Register.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402) V.1-    1936-  Volume(issue)/page/year:
   54,7740,1989

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 69270
       No. of Facilities: 3778 (estimated)
       No. of Industries: 49
       No. of Occupations: 46
       No. of Employees: 23402 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 69270
       No. of Facilities: 1439 (estimated)
       No. of Industries: 21
       No. of Occupations: 30
       No. of Employees: 16153 (estimated)
       No. of Female Employees: 1615 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
   
   EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***