*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : ST3380000
CHEMICAL NAME : m-Phenylenediamine, 4-(phenylazo)-, hydrochloride
CAS REGISTRY NUMBER : 532-82-1
LAST UPDATED : 199710
DATA ITEMS CITED : 15
MOLECULAR FORMULA : C12-H12-N4.Cl-H
MOLECULAR WEIGHT : 248.74
WISWESSER LINE NOTATION : ZR CZ DNUNR &GH
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Astra Chrysoidine R
* Brasilazina Orange Y
* Calcozine Orange YS
* Chrysoidin
* Chrysoidine
* Chrysoidine A
* Chrysoidine B
* Chrysoidine C crystals
* Chrysoidine G
* Chrysoidine GN
* Chrysoidine GS
* Chrysoidine HR
* Chrysoidine hydrochloride
* Chrysoidine (II)
* Chrysoidine J
* Chrysoidine M
* Chrysoidine Orange
* Chrysoidine PRL
* Chrysoidine PRR
* Chrysoidine SL
* Chrysoidine special (biological stain and indicator)
* Chrysoidine SS
* Chrysoidine Y
* Chrysoidine Y crystals
* Chrysoidine Y EX
* Chrysoidine YGH
* Chrysoidine YL
* Chrysoidine YN
* Chrysoidin FB
* Chrysoidin Y
* Chrysoidin YN
* Chryzoidyna F.B.
* C.I. 11270
* C.I. Basic Orange 2
* 2,4-Diaminoazobenzene hydrochloride
* Diazocard chrysoidine G
* Elcozine chrysoidine Y
* Leather Orange HR
* Nippon Kagaku Chrysoidine
* 4-(Phenylazo)-1,3-benzenediamine, monohydrochloride
* 4-Phenylazo-m-phenylenediamine hydrochloride
* 4-(Phenylazo)-m-phenylenediamine, monohydrochloride
* Pure Chrysoidine YBH
* Sugai chrysoidine
* Tertrophene Brown CG
* Verona Chrysoidine GN
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6670 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
Behavioral - muscle weakness
Gastrointestinal - nausea or vomiting
REFERENCE :
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo
Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
Volume(issue)/page/year: 105,42,1974
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5153 mg/kg/17W-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - catalases
REFERENCE :
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo
Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
Volume(issue)/page/year: 105,42,1974
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 93600 mg/kg/56W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 1,564,1982
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 94 gm/kg/57W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
XPHPAW U.S. Public Health Service Publication. (U.S. Government Printing
Office, Supt. of Documents, Washington, DC 20402) No.1- 1950-
Volume(issue)/page/year: 149,365,1969
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 9(Suppl
9),1,1987
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 100 mmol/L
REFERENCE :
MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. For English translation, see
EXMMAV. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1949-
Volume(issue)/page/year: 31,11,1979
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 100 ug/L
REFERENCE :
VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI).
All-Union Institute of Scientific and Technical Information. (Moscow, USSR)
Use information broker to obtain publications. Volume(issue)/page/year:
#428-84
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 8,91,1975
IARC Cancer Review:Human Inadequate Evidence
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,169,1987
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,169,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2097
No. of Facilities: 291 (estimated)
No. of Industries: 7
No. of Occupations: 13
No. of Employees: 3278 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M2097
No. of Facilities: 315 (estimated)
No. of Industries: 7
No. of Occupations: 14
No. of Employees: 6996 (estimated)
No. of Female Employees: 2725 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***