*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SY7525000
CHEMICAL NAME : Phosphine
CAS REGISTRY NUMBER : 7803-51-2
LAST UPDATED : 199712
DATA ITEMS CITED : 49
MOLECULAR FORMULA : H3-P
MOLECULAR WEIGHT : 34.00
WISWESSER LINE NOTATION : H3 P
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Fosforowodor
* Gas-Ex-B
* Hydrogen phosphide
* Phosphine
* Phosphorus hydride
* Phosphorus trihydride
* Phosphorwasserstoff
* RCRA waste number P096
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 1000 ppm/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TABIA2 Tabulae Biologicae. (The Hague, Netherlands) V.1-22, 1925-63.
Discontinued. Volume(issue)/page/year: 3,231,1933
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 11 ppm/4H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
36,452,1975
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 380 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,75,1982
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 70 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,75,1982
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2500 ppm/20M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
Volume(issue)/page/year: 27,314,1890
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 140 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,75,1982
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 1000 ppm/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 138,65,1928
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 200 ug/m3/24H/6W-C
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Blood - pigmented or nucleated red blood cells
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 49(1),13,1984
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3100 ppb/6H/13W-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
Blood - changes in platelet count
REFERENCE :
INHTE5 Inhalation Toxicology. (Hemisphere Publishing Corp., c/o Taylor &
Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.1- 1989-
Volume(issue)/page/year: 5,223,1993
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 ppm/4H/4D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
INHTE5 Inhalation Toxicology. (Hemisphere Publishing Corp., c/o Taylor &
Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.1- 1989-
Volume(issue)/page/year: 7,225,1995
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5 ppm/4H/2W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight
Lungs, Thorax, or Respiration - changes in lung weight
Liver - changes in liver weight
REFERENCE :
INHTE5 Inhalation Toxicology. (Hemisphere Publishing Corp., c/o Taylor &
Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.1- 1989-
Volume(issue)/page/year: 7,225,1995
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 10 ppm/4H/4D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - changes in leukocyte (WBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
INHTE5 Inhalation Toxicology. (Hemisphere Publishing Corp., c/o Taylor &
Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.1- 1989-
Volume(issue)/page/year: 7,225,1995
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5 ppm/4H/2W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight
Lungs, Thorax, or Respiration - changes in lung weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
INHTE5 Inhalation Toxicology. (Hemisphere Publishing Corp., c/o Taylor &
Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.1- 1989-
Volume(issue)/page/year: 7,225,1995
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 1400 ng/L
REFERENCE :
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H
St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year:
246,251,1989
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 5 ppm/6H/13W (Intermittent)
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
24,81,1994
*** REVIEWS ***
ACGIH TLV-STEL 1.4 mg/m3 (1 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.42 mg/m3 (0.3 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25,
1969-75(?). Discontinued. Volume(issue)/page/year: #73-19,1973
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD778-725
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.3 ppm (0.4 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,209,1971
OSHA PEL (Gen Indu):8H TWA 0.3 ppm (0.4 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.3 ppm (0.4 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.3 ppm (0.4 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.3 ppm (0.4 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.3 ppm (0.4 mg/m3) JAN 1993
OEL-AUSTRALIA:TWA 0.3 ppm (0.4 mg/m3);STEL 1 ppm (1 mg/m3) JAN 1993
OEL-BELGIUM:TWA 0.3 ppm (0.42 mg/m3);STEL 1 ppm (1.4 mg/m3) JAN 1993
OEL-DENMARK:TWA 0.1 ppm (0.15 mg/m3) JAN 1993
OEL-FINLAND:TWA 0.1 ppm (0.15 mg/m3);STEL 0.3 ppm (0.4 mg/m3) JAN 1993
OEL-FRANCE:TWA 0.1 ppm (0.13 mg/m3);STEL 0.3 ppm (0.4 mg/m3) JAN 1993
OEL-GERMANY:TWA 0.1 ppm (0.15 mg/m3) JAN 1993
OEL-HUNGARY:TWA 0.1 mg/m3;STEL 0.2 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 0.3 ppm (0.4 mg/m3);STEL 1 ppm JAN 1993
OEL-THE PHILIPPINES:TWA 0.3 ppm (0.4 mg/m3) JAN 1993
OEL-POLAND:TWA 0.1 mg/m3 JAN 1993
OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.1 ppm (0.15 mg/m3);STEL 0.2 ppm JAN 1993
OEL-THAILAND:TWA 0.3 ppm (0.4 mg/m3) JAN 1993
OEL-TURKEY:TWA 0.3 ppm (0.4 mg/m3) JAN 1993
OEL-UNITED KINGDOM:STEL 0.3 ppm (0.4 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO PHOSPHINE-air:10H TWA 0.3 ppm;STEL 1.0 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Phosphine, 6002
OSHA ANALYTICAL METHOD #ID-180
*** END OF RECORD ***