*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : SY9625000 CHEMICAL NAME : Phosphine oxide, bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)- CAS REGISTRY NUMBER : 1078-79-1 BEILSTEIN REFERENCE NO. : 1214283 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C8-H16-N3-O-P-S MOLECULAR WEIGHT : 233.30 WISWESSER LINE NOTATION : T5N CSTJ B1 APO&- AT3NTJ&- AT3NTJ SYNONYMS/TRADE NAMES : * Imiphos * Marcophan * Marcophane * Markofane *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 18700 ug/kg TOXIC EFFECTS : Blood - leukopenia REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 37,464,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 225 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - ataxia REFERENCE : 21ACAB "Imifos," Giller, S.A., ed., Izd, Riga, USSR, 1968 Volume(issue)/page/year: -,129,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 142 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - ataxia REFERENCE : 21ACAB "Imifos," Giller, S.A., ed., Izd, Riga, USSR, 1968 Volume(issue)/page/year: -,129,1968 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 65 mg/kg/9D-I TOXIC EFFECTS : Blood - leukopenia REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 37,464,1974 *** END OF RECORD ***