*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SY9625000
CHEMICAL NAME           : Phosphine oxide,
                          bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)-
CAS REGISTRY NUMBER     : 1078-79-1
BEILSTEIN REFERENCE NO. : 1214283
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C8-H16-N3-O-P-S
MOLECULAR WEIGHT        : 233.30
WISWESSER LINE NOTATION : T5N CSTJ B1 APO&- AT3NTJ&- AT3NTJ
SYNONYMS/TRADE NAMES :
   * Imiphos
   * Marcophan
   * Marcophane
   * Markofane
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 18700 ug/kg
TOXIC EFFECTS :
   Blood - leukopenia
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 37,464,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 225 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   21ACAB "Imifos," Giller, S.A., ed., Izd, Riga, USSR, 1968
   Volume(issue)/page/year: -,129,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 142 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   21ACAB "Imifos," Giller, S.A., ed., Izd, Riga, USSR, 1968
   Volume(issue)/page/year: -,129,1968
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 65 mg/kg/9D-I
TOXIC EFFECTS :
   Blood - leukopenia
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 37,464,1974
 
                            *** END OF RECORD ***