*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : SZ5821000 CHEMICAL NAME : Phosphinic amide, P,P-bis(1-aziridinyl)-N-butyl- CAS REGISTRY NUMBER : 4238-92-0 BEILSTEIN REFERENCE NO. : 1310681 LAST UPDATED : 199612 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C8-H18-N3-O-P MOLECULAR WEIGHT : 203.26 COMPOUND DESCRIPTOR : Mutagen Reproductive Effector SYNONYMS/TRADE NAMES : * P,P-Bis(1-aziridinyl)-N-butylaminophosphine oxide * P,P-Bis(1-aziridinyl)-N-butylphosphinic amide * Butylamino-bis(1-aziridinyl)phosphine oxide * ENT 51028 * Phosphine oxide, bis(1-aziridinyl)butylamino- *** HEALTH HAZARD DATA *** ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 500 ug/kg SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1955- Volume(issue)/page/year: 20,1,1974 ** MUTATION DATA ** TYPE OF TEST : Phage inhibition capacity TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 11500 umol/L REFERENCE : HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona, Sweden) V.1- 1947- Volume(issue)/page/year: 68,245,1971 TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Parenteral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 500 pmol/L REFERENCE : IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5. Volume(issue)/page/year: 38,442,1969 TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Yeast - Schizosaccharomyces pombe DOSE/DURATION : 70 mmol/L REFERENCE : HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona, Sweden) V.1- 1947- Volume(issue)/page/year: 68,245,1971 TYPE OF TEST : Dominant lethal test ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 500 ug/kg REFERENCE : FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1955- Volume(issue)/page/year: 20,1,1974 TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 33 umol/L REFERENCE : HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona, Sweden) V.1- 1947- Volume(issue)/page/year: 68,255,1971 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-nonhuman EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal; S pombe-reversion *** END OF RECORD ***