*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SZ5825000
CHEMICAL NAME           : Phosphinic amide, P,P-bis(1-aziridinyl)-N,N-dimethyl-
CAS REGISTRY NUMBER     : 1195-69-3
BEILSTEIN REFERENCE NO. : 1309282
REFERENCE               : 5-20-01-00112 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C6-H14-N3-O-P
MOLECULAR WEIGHT        : 175.20
WISWESSER LINE NOTATION : T3NTJ APO&N1&1&- AT3NTJ
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Mutagen
SYNONYMS/TRADE NAMES :
   * P,P-Bis(1-aziridinyl)-N,N-dimethylaminophosphine oxide
   * P,P-Bis(1-aziridinyl)-N,N-dimethylphosphinic amide
   * Dimethylamide diethyleneimide phosphoric acid
   * Dimethylamino-bis(1-aziridinyl)phosphine oxide
   * ENT-50990
 
                       *** HEALTH HAZARD DATA ***
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2300 umol/L
REFERENCE :
   HEREAY Hereditas (Lund, Sweden).  (Gjoerloffsgatan 121, S-261 34 Landskrona,
   Sweden)  V.1-    1947-  Volume(issue)/page/year: 68,245,1971
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 500 pmol/L
REFERENCE :
   IMSUAI Industrial Medicine and Surgery.  (Northbrook, IL)  V.18-42, 1949-73.
    For publisher information, see IOHSA5.  Volume(issue)/page/year:
   38,442,1969
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Schizosaccharomyces pombe
DOSE/DURATION           : 70 mmol/L
REFERENCE :
   HEREAY Hereditas (Lund, Sweden).  (Gjoerloffsgatan 121, S-261 34 Landskrona,
   Sweden)  V.1-    1947-  Volume(issue)/page/year: 68,245,1971
 
TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 24 mmol/L
REFERENCE :
   CNJGA8 Canadian Journal of Genetics and Cytology.  (National Research
   Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
   Canada)  V.1-    1959-  Volume(issue)/page/year: 11,648,1969
 
TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 24 mmol/L
REFERENCE :
   CNJGA8 Canadian Journal of Genetics and Cytology.  (National Research
   Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
   Canada)  V.1-    1959-  Volume(issue)/page/year: 11,648,1969
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 2 mg/L
REFERENCE :
   TGANAK Tsitologiya i Genetika.  Cytology and Genetics.  For English
   translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-    1967-  Volume(issue)/page/year: 16(2),34,1982
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 33 umol/L
REFERENCE :
   HEREAY Hereditas (Lund, Sweden).  (Gjoerloffsgatan 121, S-261 34 Landskrona,
   Sweden)  V.1-    1947-  Volume(issue)/page/year: 68,255,1971

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-nonhuman
   
   EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal; S
   pombe-reversion

 
                            *** END OF RECORD ***