*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SZ5827000
CHEMICAL NAME : Phosphinic amide,
P,P-bis(1-aziridinyl)-N-(2-(dimethylamino)-7-methyl-7
H-purin-6-yl)-
CAS REGISTRY NUMBER : 42061-52-9
BEILSTEIN REFERENCE NO. : 1036986
LAST UPDATED : 199612
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C12-H19-N8-O-P
MOLECULAR WEIGHT : 322.36
WISWESSER LINE NOTATION : T56 BN DN FN HNJ B1 GN1&1 IMPO&- AT3NTJ&- AT3NTJ
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* P,P-Bis(1-aziridinyl)-N-(2-(dimethylamino)-7-methyl-7H-purin-6-yl)phosph
inic amide
* 2-Dimethylamino-6-diethylenimidophosphamido-7-methylpurine
* Fopurin
* Fopurine
* Phopurine
* Phopurinum
* Pumitepa
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979-
Volume(issue)/page/year: 2(5),73,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
8,132,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 280 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-
1967- Volume(issue)/page/year: 14,363,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
8,132,1983
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
8,132,1983
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 5 umol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
54,113,1990
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 5 umol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
47,53,1989
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 150 mg/kg
REFERENCE :
EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979-
Volume(issue)/page/year: 2(5),73,1980
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 125 mg/kg
REFERENCE :
IANBAM Izvestiya Akademii Nauk SSSR, Seriya Biologicheskaya. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1936-
Volume(issue)/page/year: (6),816,1991
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 24 mg/kg
REFERENCE :
BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny. Bulletin of
Experimental Biology and Medicine. For English translation, see BEXBAN.
(V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 102(7),76,1986
*** END OF RECORD ***