*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SZ5828500
CHEMICAL NAME           : Phosphinic amide, P,P-bis(1-aziridinyl)-N-isopropyl-
CAS REGISTRY NUMBER     : 5774-35-6
LAST UPDATED            : 198910
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C7-H16-N3-O-P
MOLECULAR WEIGHT        : 189.23
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * P,P-Bis(1-aziridinyl)-N-isopropylaminophosphine oxide
   * P,P-Bis(1-aziridinyl)-N-isopropylphosphinic amide
   * ENT 51256
   * Phosphinic amide, P,P-bis(1-aziridinyl)-N-(1-methylethyl)-
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 500 ug/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   FOBLAN Folia Biologica (Prague).  (Academic Press Inc. Ltd., 24-28 Oval Rd.,
   London NW1 7DX, UK) V.1-    1955-  Volume(issue)/page/year: 20,1,1974
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2300 umol/L
REFERENCE :
   HEREAY Hereditas (Lund, Sweden).  (Gjoerloffsgatan 121, S-261 34 Landskrona,
   Sweden)  V.1-    1947-  Volume(issue)/page/year: 68,245,1971
 
TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 6 mmol/kg
REFERENCE :
   FOBLAN Folia Biologica (Prague).  (Academic Press Inc. Ltd., 24-28 Oval Rd.,
   London NW1 7DX, UK) V.1-    1955-  Volume(issue)/page/year: 20,1,1974
 
TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 500 ug/kg
REFERENCE :
   FOBLAN Folia Biologica (Prague).  (Academic Press Inc. Ltd., 24-28 Oval Rd.,
   London NW1 7DX, UK) V.1-    1955-  Volume(issue)/page/year: 20,1,1974
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 33 umol/L
REFERENCE :
   HEREAY Hereditas (Lund, Sweden).  (Gjoerloffsgatan 121, S-261 34 Landskrona,
   Sweden)  V.1-    1947-  Volume(issue)/page/year: 68,255,1971

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-nonhuman
   
   EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal

 
                            *** END OF RECORD ***