*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SZ6116000
CHEMICAL NAME           : Phospholipase C
CAS REGISTRY NUMBER     : 9001-86-9
LAST UPDATED            : 198706
DATA ITEMS CITED        : 3
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * E.C. 3.1.4.3
   * Lecithinase C
   * Lipophosphodiesterase
   * Phosphotidase C
   * PLC
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SJCLAY Scandinavian Journal of Clinical and Laboratory Investigation.
   (Blackwell Scientific Pub. Inc., 52 Beacon St., Boston, MA 02108)  V.1-
   1949-  Volume(issue)/page/year: 36,553,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 450 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SJCLAY Scandinavian Journal of Clinical and Laboratory Investigation.
   (Blackwell Scientific Pub. Inc., 52 Beacon St., Boston, MA 02108)  V.1-
   1949-  Volume(issue)/page/year: 42,239,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - domestic
DOSE/DURATION           : 200 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Gastrointestinal - changes in structure or function of salivary glands
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   SJCLAY Scandinavian Journal of Clinical and Laboratory Investigation.
   (Blackwell Scientific Pub. Inc., 52 Beacon St., Boston, MA 02108)  V.1-
   1949-  Volume(issue)/page/year: 43,445,1983
 
                            *** END OF RECORD ***