*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : SZ6116000 CHEMICAL NAME : Phospholipase C CAS REGISTRY NUMBER : 9001-86-9 LAST UPDATED : 198706 DATA ITEMS CITED : 3 COMPOUND DESCRIPTOR : Drug Natural Product SYNONYMS/TRADE NAMES : * E.C. 3.1.4.3 * Lecithinase C * Lipophosphodiesterase * Phosphotidase C * PLC *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SJCLAY Scandinavian Journal of Clinical and Laboratory Investigation. (Blackwell Scientific Pub. Inc., 52 Beacon St., Boston, MA 02108) V.1- 1949- Volume(issue)/page/year: 36,553,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 450 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SJCLAY Scandinavian Journal of Clinical and Laboratory Investigation. (Blackwell Scientific Pub. Inc., 52 Beacon St., Boston, MA 02108) V.1- 1949- Volume(issue)/page/year: 42,239,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - domestic DOSE/DURATION : 200 ug/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - chronic pulmonary edema Gastrointestinal - changes in structure or function of salivary glands Kidney, Ureter, Bladder - urine volume increased REFERENCE : SJCLAY Scandinavian Journal of Clinical and Laboratory Investigation. (Blackwell Scientific Pub. Inc., 52 Beacon St., Boston, MA 02108) V.1- 1949- Volume(issue)/page/year: 43,445,1983 *** END OF RECORD ***