*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SZ6185000
CHEMICAL NAME           : Phosphonamidic acid,
                          p-(1-aziridinyl)-N-(2-nicotinoylethyl)-,
                          p-((bis(1-aziridinyl) phosphinyl)oxy)phenyl ester
CAS REGISTRY NUMBER     : 34691-29-7
LAST UPDATED            : 198812
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C20-H25-N5-O5-P2
MOLECULAR WEIGHT        : 477.44
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * A-272
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FATOBP Farmakologiya i Toksikologiya (Kiev).  Pharmacology and Toxicology.
   (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii,
   Kiev, USSR)  No.1-    1964-  Volume(issue)/page/year: 6,145,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FATOBP Farmakologiya i Toksikologiya (Kiev).  Pharmacology and Toxicology.
   (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii,
   Kiev, USSR)  No.1-    1964-  Volume(issue)/page/year: 6,145,1971
 
                            *** END OF RECORD ***