*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SZ6187000
CHEMICAL NAME           : Phosphonamidic acid,
                          p-(1-aziridinyl)-N-(2-nicotinoylethyl)-, p-phenylene
                          ester
CAS REGISTRY NUMBER     : 40951-24-4
LAST UPDATED            : 198812
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C26-H30-N6-O6-P2
MOLECULAR WEIGHT        : 584.56
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * A-273
   * p-(1-Aziridinyl)-N-(2-nicotinoylethyl)phosphonamidic acid p-phenylene  
   ester
   * Diethylenediamide di(2-(nicotinoyl)ethylamino)-p-phenylenediphosphoric  
   acid
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FATOBP Farmakologiya i Toksikologiya (Kiev).  Pharmacology and Toxicology.
   (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii,
   Kiev, USSR)  No.1-    1964-  Volume(issue)/page/year: 6,145,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FATOBP Farmakologiya i Toksikologiya (Kiev).  Pharmacology and Toxicology.
   (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii,
   Kiev, USSR)  No.1-    1964-  Volume(issue)/page/year: 6,145,1971
 
                            *** END OF RECORD ***