*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SZ7640500
CHEMICAL NAME : Phosphonic acid, (dichloromethylene)bis-
CAS REGISTRY NUMBER : 10596-23-3
BEILSTEIN REFERENCE NO. : 1876367
LAST UPDATED : 199612
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C-H4-Cl2-O6-P2
MOLECULAR WEIGHT : 244.89
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Clodronic acid
* (Dichloromethylene)bisphosphonic acid
* Dichloromethylenediphosphonic acid
* Methanedichlorodiphosphonic acid
* Phosphonic acid, (dichloromethylene)di-
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2500 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 266,1691,1993
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 266,1691,1993
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 800 mg/kg/4D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
Kidney, Ureter, Bladder - other changes in urine composition
Nutritional and Gross Metabolic - changes in iron
REFERENCE :
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert
Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)-
1978- Volume(issue)/page/year: 15,365,1987
*** END OF RECORD ***