*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : SZ7640700 CHEMICAL NAME : Phosphonic acid, (dichloromethylene)bis-, disodium salt CAS REGISTRY NUMBER : 22560-50-5 LAST UPDATED : 199512 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C-H2-Cl2-O6-P2.2Na MOLECULAR WEIGHT : 288.85 SYNONYMS/TRADE NAMES : * BM 06011 * Chlodronate sodium * Dichloromethane diphosphonate * Disodium (dichloromethylene)bisphosphonate * Phosphonic acid, (dichloromethylene)di-, disodium salt *** HEALTH HAZARD DATA *** ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3600 mg/kg/15D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - hematuria Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) REFERENCE : TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 17,27,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1200 mg/kg/3D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - hematuria Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) REFERENCE : TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 17,27,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - pig DOSE/DURATION : 182 gm/kg/26W-I TOXIC EFFECTS : Musculoskeletal - changes in teeth and supporting structures Musculoskeletal - other changes Related to Chronic Data - death REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 59,129,1986 *** END OF RECORD ***