*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SZ7640700
CHEMICAL NAME           : Phosphonic acid, (dichloromethylene)bis-, disodium
                          salt
CAS REGISTRY NUMBER     : 22560-50-5
LAST UPDATED            : 199512
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C-H2-Cl2-O6-P2.2Na
MOLECULAR WEIGHT        : 288.85
SYNONYMS/TRADE NAMES :
   * BM 06011
   * Chlodronate sodium
   * Dichloromethane diphosphonate
   * Disodium (dichloromethylene)bisphosphonate
   * Phosphonic acid, (dichloromethylene)di-, disodium salt
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3600 mg/kg/15D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - proteinuria
   Kidney, Ureter, Bladder - hematuria
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   TOPADD Toxicologic Pathology.  (c/o Dr. F.A. de la Iglesia, Warner-Lambert
   Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 
     1978-  Volume(issue)/page/year: 17,27,1989
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 mg/kg/3D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Kidney, Ureter, Bladder - hematuria
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   TOPADD Toxicologic Pathology.  (c/o Dr. F.A. de la Iglesia, Warner-Lambert
   Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 
     1978-  Volume(issue)/page/year: 17,27,1989
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - pig
DOSE/DURATION           : 182 gm/kg/26W-I
TOXIC EFFECTS :
   Musculoskeletal - changes in teeth and supporting structures
   Musculoskeletal - other changes
   Related to Chronic Data - death
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   59,129,1986
 
                            *** END OF RECORD ***