*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : SZ1300000 CHEMICAL NAME : Phosphine oxide, 1,4-piperazinediylbis(bis(1-aziridinyl)- CAS REGISTRY NUMBER : 738-99-8 BEILSTEIN REFERENCE NO. : 0629375 REFERENCE : 5-23-03-00231 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 14 MOLECULAR FORMULA : C12-H24-N6-O2-P2 MOLECULAR WEIGHT : 346.36 WISWESSER LINE NOTATION : T6N DNTJ APO&- AT3NTJ&- AT3NTJ& DPO&- AT3NTJ&- AT3NTJ COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * 1,4-Bis(N,N'-diethylene phosphamide)piperazine * Dipin * Dipine * ENT-50107 * Piperazine, 1,4-bis(bis(1-aziridinyl)phosphinyl)- * 1,4-Piperazinediylbis(bis(1-aziridinyl)phosphine oxide) * Tetra-ethyleneimidepiperazine-N,N'-diphosphoric acid *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 68 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 36,240,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 14,363,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 58 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 21,262,1976 ** MUTATION DATA ** TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Parenteral TEST SYSTEM : Insect - not otherwise specified DOSE/DURATION : 24 mmol/L REFERENCE : CNJGA8 Canadian Journal of Genetics and Cytology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1959- Volume(issue)/page/year: 11,648,1969 TYPE OF TEST : Dominant lethal test ROUTE OF EXPOSURE : Unreported TEST SYSTEM : Insect - not otherwise specified DOSE/DURATION : 1 pph/3H (Continuous) REFERENCE : AESAAI Annals of the Entomological Society of America. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1908- Volume(issue)/page/year: 62,790,1969 TYPE OF TEST : Dominant lethal test ROUTE OF EXPOSURE : Parenteral TEST SYSTEM : Insect - not otherwise specified DOSE/DURATION : 24 mmol/L REFERENCE : CNJGA8 Canadian Journal of Genetics and Cytology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1959- Volume(issue)/page/year: 11,648,1969 TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 29 umol/L REFERENCE : SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 10,1580,1974 TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 10 mg/L REFERENCE : TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 16(2),34,1982 TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - rat DOSE/DURATION : 60 mg/kg REFERENCE : SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 11,1347,1975 TYPE OF TEST : DNA inhibition ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 60 mg/kg REFERENCE : IANBAM Izvestiya Akademii Nauk SSSR, Seriya Biologicheskaya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1936- Volume(issue)/page/year: (6),816,1991 TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 10 mg/kg REFERENCE : CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 19(1),23,1985 TYPE OF TEST : Sister chromatid exchange ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 2 mg/kg REFERENCE : CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 19(1),23,1985 TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Cells - not otherwise specified DOSE/DURATION : 5700 nmol/L REFERENCE : SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 18,210,1982 TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Mammal - pig DOSE/DURATION : 20 mg/kg REFERENCE : CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 10(6),54,1976 *** END OF RECORD ***