*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SZ8562100
CHEMICAL NAME           : Phosphonic acid, (1-hydroxyethylidene)di-
CAS REGISTRY NUMBER     : 2809-21-4
OTHER CAS REGISTRY NOS. : 106908-76-3
BEILSTEIN REFERENCE NO. : 1789291
REFERENCE               : 0-02-00-00171 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C2-H8-O7-P2
MOLECULAR WEIGHT        : 206.04
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Dequest 2010
   * Dequest 2015
   * Dequest Z 010
   * EHDP
   * Ethane-1-hydroxy-1,1-diphosphonate
   * 1,1,1-Ethanetriol diphosphonate
   * Etidronic acid
   * Ferrofos 510
   * HEDP
   * 1-Hydroxy-1,1-diphosphonoethane
   * Hydroxyethanediphosphonic acid
   * 1-Hydroxyethanediphosphonic acid
   * Oxyethylidenediphosphonic acid
   * Phosphonic acid, 1-hydroxy-1,1-ethanediyl ester
   * Phosphonic acid, (1-hydroxyethylidene)bis-
   * 1000SL
   * Turpinal SL
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ACIEAY Angewandte Chemie, International Edition in English.  (VCH Pub.,
   Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441)  V.1-    1962-
   Volume(issue)/page/year: 14,94,1975
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 40 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   SIGAAE Shika Igaku.  Odontology.  (Osaka Shika Gakkai, 1-47 Kyobashi,
   Higashi-ku, Osaka 540, Japan) V.1-    1930-  Volume(issue)/page/year:
   50,879,1987
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 200 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - blood and lymphatic
   systems (including spleen and marrow)
REFERENCE :
   JODUA2 Journal of Osaka Dental University.  (Osaka Dental Univ., 1-47,
   Kyobashi Higashi-ku, Osaka 540, Japan)  V.1-    1967-
   Volume(issue)/page/year: 20,91,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 200 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JODUA2 Journal of Osaka Dental University.  (Osaka Dental Univ., 1-47,
   Kyobashi Higashi-ku, Osaka 540, Japan)  V.1-    1967-
   Volume(issue)/page/year: 19,87,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 200 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   SIGAAE Shika Igaku.  Odontology.  (Osaka Shika Gakkai, 1-47 Kyobashi,
   Higashi-ku, Osaka 540, Japan) V.1-    1930-  Volume(issue)/page/year:
   49,837,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 200 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 26(1),16A,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1400 mg/kg
SEX/DURATION            : female 11-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
   information, see CGANE7.  Volume(issue)/page/year: 22,47,1982

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M0985
       No. of Facilities: 404 (estimated)
       No. of Industries: 10
       No. of Occupations: 7
       No. of Employees: 6655 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M0985
       No. of Facilities: 3273 (estimated)
       No. of Industries: 73
       No. of Occupations: 46
       No. of Employees: 44885 (estimated)
       No. of Female Employees: 3814 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***