*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SZ1750000
CHEMICAL NAME : Phosphine oxide, tris(1-aziridinyl)-
CAS REGISTRY NUMBER : 545-55-1
BEILSTEIN REFERENCE NO. : 0145971
REFERENCE : 4-20-00-00048 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 68
MOLECULAR FORMULA : C6-H12-N3-O-P
MOLECULAR WEIGHT : 173.18
WISWESSER LINE NOTATION : T3NTJ APO&- AT3NTJ&- AT3NTJ
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* A 6366
* Aphoxide
* APO
* Aziridine, 1,1',1"-phosphinylidynetris-
* CBC 906288
* ENT 24915
* Imperon fixer T
* NSC 9717
* 1,1',1''-Phosphinylidynetrisaziridine
* Phosphoramide, N,N',N"-triethylene-
* Phosphoric acid triethylene imide
* Phosphoric triamide, N,N',N''-tri-1,2-ethanediyl-
* Phosphoric triamide, N,N',N"-triethylene-
* SK-3818
* TAPO
* TEF
* TEPA
* Triaethylenphosphorsaeureamid
* Triaziridinophosphine oxide
* Triaziridinylphosphine oxide
* Tri(aziridinyl)phosphine oxide
* Tri-1-aziridinylphosphine oxide
* Tri(1-aziridinyl)phosphine oxide
* N,N',N''-Tri-1,2-ethanediylphosphoric triamide
* Triethylenephosphoramide
* N,N',N"-Triethylenephosphoramide
* Triethylenephosphoric triamide
* N,N',N''-Triethylenephosphoric triamide
* Triethylenephosphorotriamide
* Triethylenfosforamid
* Tris(1-aziridine)phosphine oxide
* Tris-(1-aziridinyl)fosfinoxid
* Tris(aziridinyl)phosphine oxide
* Tris(1-aziridinyl)phosphine oxide
* Tris(N-ethylene)phosphorotriamidate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 37 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Gastrointestinal - hypermotility, diarrhea
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
BWHOA6 Bulletin of the World Health Organization. (WHO, Pub. Center USA, 49
Sheridan Ave., Albany, NY 12210) Volume(issue)/page/year: 31,737,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 87 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal)
Gastrointestinal - hypermotility, diarrhea
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
BWHOA6 Bulletin of the World Health Organization. (WHO, Pub. Center USA, 49
Sheridan Ave., Albany, NY 12210) Volume(issue)/page/year: 31,737,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 25,223,1965
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 420 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
REFERENCE :
KOBUA3 Kobunshi. High Polymers. (Kobunshi Gakkai, 5-12-8, Ginza, Chuo-Ku,
Tokyo 104, Japan) V.1- 1952- Volume(issue)/page/year: 24,788,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 25500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 25,223,1965
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 178 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
Volume(issue)/page/year: NX#02129
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 430 ug/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Blood - leukopenia
Blood - other changes
REFERENCE :
CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5,
1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year:
2,202,1965
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 870 ug/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Blood - leukopenia
Blood - other changes
REFERENCE :
CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5,
1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year:
2,202,1965
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 151 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - ataxia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
16,100,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - quail
DOSE/DURATION : 237 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 48,371,1976
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - domestic
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
Lungs, Thorax, or Respiration - cyanosis
Liver - hepatitis (hepatocellular necrosis), diffuse
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of
Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
Volume(issue)/page/year: 111,715,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 15 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation,
see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10,
1928-37; V.1- 1955- Volume(issue)/page/year: 26(5),54,1980
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1300 ug/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
41,985,1968
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3120 ug/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
41,985,1968
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 5 mg/kg
SEX/DURATION : female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
16,805,1968
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 7500 mg/kg
SEX/DURATION : female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
16,805,1968
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intratesticular
SPECIES OBSERVED : Rodent - rat
DOSE : 2 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 22,175,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 2500 ug/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Newborn - germ cell effects (in offspring)
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval Rd.,
London NW1 7DX, UK) V.1- 1955- Volume(issue)/page/year: 16,367,1970
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 10 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 225,1260,1970
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 10 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females
per # females mated; # copulations per # estrus cycles)
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
Reproductive - Fertility - other measures of fertility
REFERENCE :
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264)
V.1- 1916- Volume(issue)/page/year: 65,483,1970
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 312 ug/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
23,288,1972
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 2500 ug/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
23,288,1972
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intratesticular
SPECIES OBSERVED : Rodent - hamster
DOSE : 4 mg/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 22,175,1980
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 5 ug/plate
REFERENCE :
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301
N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
Volume(issue)/page/year: 1(1),21,1984
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 5 mg/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 28,405,1975
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 2300 umol/L
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona,
Sweden) V.1- 1947- Volume(issue)/page/year: 68,245,1971
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 50 umol/L/48H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 222,359,1989
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 500 ug/kg
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St.,
New York, NY 10013) V.1- 1972- Volume(issue)/page/year: 24,917,1981
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 300 pmol/L
REFERENCE :
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73.
For publisher information, see IOHSA5. Volume(issue)/page/year:
38,442,1969
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 500 ug/kg
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St.,
New York, NY 10013) V.1- 1972- Volume(issue)/page/year: 24,917,1981
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 100 umol/L
REFERENCE :
FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval Rd.,
London NW1 7DX, UK) V.1- 1955- Volume(issue)/page/year: 18,139,1972
TYPE OF TEST : Heritable translocation test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 200 umol/L
REFERENCE :
FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval Rd.,
London NW1 7DX, UK) V.1- 1955- Volume(issue)/page/year: 18,139,1972
TYPE OF TEST : Heritable translocation test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 500 ug/kg
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St.,
New York, NY 10013) V.1- 1972- Volume(issue)/page/year: 24,917,1981
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 10 mmol/L
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona,
Sweden) V.1- 1947- Volume(issue)/page/year: 68,245,1971
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Yeast - Schizosaccharomyces pombe
DOSE/DURATION : 2300 umol/L
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St.,
New York, NY 10013) V.1- 1972- Volume(issue)/page/year: 24,917,1981
TYPE OF TEST : Specific locus test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - silkworm
DOSE/DURATION : 5 ug
REFERENCE :
KIKNAJ Kokuritsu Idengaku Kenkyusho Nenpo. Annual Report of the National
Institute of Genetics. (Kokuritsu Idengaku Kenkyusho, 1111 Yata, Mishima,
Shizuoka-ken 411, Japan) No. 1- 1949- Volume(issue)/page/year:
(30),72,1979
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 4800 umol/L
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.1- 1959- Volume(issue)/page/year: 11,648,1969
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 1000 ppm
REFERENCE :
ABABAC Annales de Biologie Animale, Biochimie, Biophysique. (Versailles,
France) V.1-19, 1961-79. Volume(issue)/page/year: 17,661,1977
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 4800 umol/L
REFERENCE :
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research
Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
Canada) V.1- 1959- Volume(issue)/page/year: 11,648,1969
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 5 ppm
REFERENCE :
BWHOA6 Bulletin of the World Health Organization. (WHO, Pub. Center USA, 49
Sheridan Ave., Albany, NY 12210) Volume(issue)/page/year: 47,305,1972
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 10 ug
REFERENCE :
BEREA2 Bulletin of Entomological Research. (CAB International, Central
Sales, Farnham House, Farnham Royal, Slough SL2 3BN, UK) V.1- 1910-
Volume(issue)/page/year: 62,401,1973
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 1 ug
REFERENCE :
BEREA2 Bulletin of Entomological Research. (CAB International, Central
Sales, Farnham House, Farnham Royal, Slough SL2 3BN, UK) V.1- 1910-
Volume(issue)/page/year: 62,401,1973
TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - not otherwise specified
DOSE/DURATION : 1000 ppm
REFERENCE :
ABABAC Annales de Biologie Animale, Biochimie, Biophysique. (Versailles,
France) V.1-19, 1961-79. Volume(issue)/page/year: 17,661,1977
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 20 ug/L
REFERENCE :
HUGEDQ Human Genetics. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.31- 1976- Volume(issue)/page/year:
49,41,1979
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 100 umol/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1939- Volume(issue)/page/year:
24,314,1968
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 125 ug/L
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
10013) V.41- 1956- Volume(issue)/page/year: 82,1581,1976
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 100 ng/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 53,215,1978
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 10 mg/kg/24H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 65,121,1979
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - mouse Leukocyte
DOSE/DURATION : 1 umol/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
41,157,1988
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 1 mg/kg
REFERENCE :
FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval Rd.,
London NW1 7DX, UK) V.1- 1955- Volume(issue)/page/year: 21,60,1975
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 40 ug/kg
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
17,23,1970
TYPE OF TEST : Sperm Morphology
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 4 mg/kg
REFERENCE :
REBPAT Radiation and Environmental Biophysics. (Springer-Verlag New York,
Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.11- 1974-
Volume(issue)/page/year: 13,1,1976
TYPE OF TEST : Heritable translocation test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 2500 ug/kg
REFERENCE :
REBPAT Radiation and Environmental Biophysics. (Springer-Verlag New York,
Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.11- 1974-
Volume(issue)/page/year: 13,1,1976
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - hamster
DOSE/DURATION : 5 mg/kg
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St.,
New York, NY 10013) V.1- 1972- Volume(issue)/page/year: 24,917,1981
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 33 umol/L
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St.,
New York, NY 10013) V.1- 1972- Volume(issue)/page/year: 24,433,1981
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION : 1400 nmol/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year:
18,210,1982
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 9,75,1975
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 9,75,1975
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*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Positive: Rodent dominant lethal; Rodent heritable
translocation
EPA GENETOX PROGRAM 1988, Positive: N crassa-forward mutation
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal; S
pombe-reversion
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat;
Cytogenetics-male germ cell
*** END OF RECORD ***