*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TA1400000
CHEMICAL NAME           : Phosphonic diamide,
                          p-(5-amino-3-phenyl-1H-1,2,4-triazol-1-yl)-N,N,N',N'-
                          tetramethyl-
CAS REGISTRY NUMBER     : 1031-47-6
BEILSTEIN REFERENCE NO. : 0551608
REFERENCE               : 5-26-08-00190 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C12-H19-N6-O-P
MOLECULAR WEIGHT        : 294.34
WISWESSER LINE NOTATION : T5NN DNJ APON1&1&N1&1 CR& EZ
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 5-Amino-1-bis(dimethylamide)phosphoryl-3-phenyl-1,2,4-triazole
   * 5-Amino-1-(bis(dimethylamino)phosphinyl)-3-phenyl-1,2,4-triazole
   * 5-Amino-1-bis(dimethylamido)phosphoryl-3-phenyl-1,2,4-triazole
   * 5-Amino-3-fenil-1-bis(-dimetilamino)-fosforil-1,2,4-triazolo
   * 5-Amino-3-fenyl-1-bis(dimethyl-amino)-fosforyl-1,2,4-triazool
   * 5-Amino-3-phenyl-1-bis (dimethyl-amino)-phosphoryle-1,2,4-triazole
   * 5-Amino-3-phenyl-1-bis(dimethylamino)-phosphoryl-1H-1,2,4-triazol
   * 5-Amino-3-phenyl-1,2,4-triazole-1-yl-N,N,N',N'-tetramethylphosphodiamide
   * 5-Amino-3-phenyl-1,2,4-triazolyl-1-bis(dimethylamido)pheosphate
   * 5-Amino-3-phenyl-1,2,4-triazolylbis(dimethylamino)-phosphinoxid
   * 5-Amino-3-phenyl-1,2,4-triazolyl-nnn'N'-tetramethyl-phosphonamide
   * p-(5-Amino-3-phenyl-1H-1,2,4-triazol-1-yl)-N,N,N'-tetramethyl phosphonic  
   diamide
   * Bis(dimethylamino)-3-amino-5-phenyltriazolyl phosphine oxide
   * Niagara 5943
   * 3-Phenyl-5-amino-1,2,4-triazolyl-(1)-(N,N'-tetramethyl)  
   diamidophosphonate
   * Triamifos
   * Triamiphos
   * Triamphos
   * Wepsin
   * Wepsyn
   * Wepsyn 155
   * WP 155
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMCHA2 Farm Chemicals Handbook.  (Meister Pub., 37841 Euclid Ave.,
   Willoughy, OH 44094)  Volume(issue)/page/year: -,C325,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 48 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   WRPCA2 World Review of Pest Control.  (London, UK)  V.1-10, 1962-71.
   Discontinued.  Volume(issue)/page/year: 9,119,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Lungs, Thorax, or Respiration - other changes
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
REFERENCE :
   EJPHAZ European Journal of Pharmacology.  (Elsevier Science Pub. B.V., POB
   211, 1000 AE Amsterdam, Netherlands)  V.1-    1967- Volume(issue)/page/year:
   16,361,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
   New York, Inc., 1971  Volume(issue)/page/year: -,427,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARSIM* Agricultural Research Service, USDA Information Memorandum.
   (Beltsville, MD 20705)  Volume(issue)/page/year: 20,27,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GUCHAZ Guide to the Chemicals Used in Crop Protection.  (Information Canada,
   171 Slater St., Ottawa, Ont., Canada)  Volume(issue)/page/year: 6,508,1973
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1315 ug/kg
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - hepatobiliary system
   Reproductive - Specific Developmental Abnormalities - endocrine system
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 2,327,1974
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6575 ug/kg
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - blood and lymphatic
   systems (including spleen and marrow)
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 2,327,1974

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   RREVAH Residue Reviews.  (Springer-Verlag New York, Inc., Service Center, 44
   Hartz Way, Secaucus, NJ 07094)  V.1-    1962-  Volume(issue)/page/year:
   53,99,1974

 
                            *** END OF RECORD ***