*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TA1400000 CHEMICAL NAME : Phosphonic diamide, p-(5-amino-3-phenyl-1H-1,2,4-triazol-1-yl)-N,N,N',N'- tetramethyl- CAS REGISTRY NUMBER : 1031-47-6 BEILSTEIN REFERENCE NO. : 0551608 REFERENCE : 5-26-08-00190 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C12-H19-N6-O-P MOLECULAR WEIGHT : 294.34 WISWESSER LINE NOTATION : T5NN DNJ APON1&1&N1&1 CR& EZ COMPOUND DESCRIPTOR : Agricultural Chemical Reproductive Effector SYNONYMS/TRADE NAMES : * 5-Amino-1-bis(dimethylamide)phosphoryl-3-phenyl-1,2,4-triazole * 5-Amino-1-(bis(dimethylamino)phosphinyl)-3-phenyl-1,2,4-triazole * 5-Amino-1-bis(dimethylamido)phosphoryl-3-phenyl-1,2,4-triazole * 5-Amino-3-fenil-1-bis(-dimetilamino)-fosforil-1,2,4-triazolo * 5-Amino-3-fenyl-1-bis(dimethyl-amino)-fosforyl-1,2,4-triazool * 5-Amino-3-phenyl-1-bis (dimethyl-amino)-phosphoryle-1,2,4-triazole * 5-Amino-3-phenyl-1-bis(dimethylamino)-phosphoryl-1H-1,2,4-triazol * 5-Amino-3-phenyl-1,2,4-triazole-1-yl-N,N,N',N'-tetramethylphosphodiamide * 5-Amino-3-phenyl-1,2,4-triazolyl-1-bis(dimethylamido)pheosphate * 5-Amino-3-phenyl-1,2,4-triazolylbis(dimethylamino)-phosphinoxid * 5-Amino-3-phenyl-1,2,4-triazolyl-nnn'N'-tetramethyl-phosphonamide * p-(5-Amino-3-phenyl-1H-1,2,4-triazol-1-yl)-N,N,N'-tetramethyl phosphonic diamide * Bis(dimethylamino)-3-amino-5-phenyltriazolyl phosphine oxide * Niagara 5943 * 3-Phenyl-5-amino-1,2,4-triazolyl-(1)-(N,N'-tetramethyl) diamidophosphonate * Triamifos * Triamiphos * Triamphos * Wepsin * Wepsyn * Wepsyn 155 * WP 155 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C325,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 48 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Lungs, Thorax, or Respiration - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase REFERENCE : EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 16,361,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 Volume(issue)/page/year: -,427,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705) Volume(issue)/page/year: 20,27,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,508,1973 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 1315 ug/kg SEX/DURATION : multigenerations TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - hepatobiliary system Reproductive - Specific Developmental Abnormalities - endocrine system Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 2,327,1974 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 6575 ug/kg SEX/DURATION : multigenerations TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 2,327,1974 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 53,99,1974 *** END OF RECORD ***