*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TA1840700
CHEMICAL NAME           : Phosphonic difluoride, methyl-
CAS REGISTRY NUMBER     : 676-99-3
BEILSTEIN REFERENCE NO. : 1739375
REFERENCE               : 4-04-00-03508 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C-H3-F2-O-P
MOLECULAR WEIGHT        : 100.01
WISWESSER LINE NOTATION : OPFF1
SYNONYMS/TRADE NAMES :
   * Difluoro
   * Difluoromethylphosphine oxide
   * Methyl difluorophosphite
   * Methylphosphonic difluoride
   * Methylphosphonyldifluoride
   * Phosphonodifluoridic acid, methyl-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1842 mg/m3/30M
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Skin and Appendages - dermatitis, other (after systemic exposure)
   Skin and Appendages - hair
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   15,131,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13700 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
   National Cancer Institute, Memorandum, June 17, 1974
   Volume(issue)/page/year: 17JUN1974
 
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1842 mg/m3/30M
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - muscle weakness
   Behavioral - ataxia
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   15,131,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 114 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
   National Cancer Institute, Memorandum, June 17, 1974
   Volume(issue)/page/year: 17JUN1974
 
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1842 mg/m3/30M
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Lungs, Thorax, or Respiration - cyanosis
   Nutritional and Gross Metabolic - dehydration
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   15,131,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 25800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
   National Cancer Institute, Memorandum, June 17, 1974
   Volume(issue)/page/year: 17JUN1974
 
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 2608 mg/m3/30M
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Behavioral - aggression
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   15,131,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 26900 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
   National Cancer Institute, Memorandum, June 17, 1974
   Volume(issue)/page/year: 17JUN1974
 
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1600 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 4,22,1984

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***