*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : TB4970000
CHEMICAL NAME : Phosphoramidothioic acid, O,S-dimethyl ester
CAS REGISTRY NUMBER : 10265-92-6
BEILSTEIN REFERENCE NO. : 1098870
LAST UPDATED : 199710
DATA ITEMS CITED : 31
MOLECULAR FORMULA : C2-H8-N-O2-P-S
MOLECULAR WEIGHT : 141.14
WISWESSER LINE NOTATION : 1SPZS&O1
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Acephate-met
* BAY 71628
* Bayer 71628
* Chevron 9006
* Chevron ortho 9006
* O,S-Dimethyl ester amide of amidothioate
* O,S-Dimethyl phosphoramidothioate
* ENT 27,396
* Hamidop
* Metamidofos estrella
* Methamidophos
* Monitor
* NSC 190987
* Ortho 9006
* Pillaron
* SRA 5172
* Tahmabon
* Tamaron
* Thiophosphorsaeure-O,S-dimethylesteramid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 257 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
Skin and Appendages - sweating
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year:
306,125,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 360 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
Skin and Appendages - sweating
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year:
306,125,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 600 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Autonomic Nervous System - parasympatholytic
Behavioral - coma
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 14,390,1994
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARSIM* Agricultural Research Service, USDA Information Memorandum.
(Beltsville, MD 20705) Volume(issue)/page/year: 20,7,1966
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 162 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd,
eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year:
A265,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
Science Pub., 1969 Volume(issue)/page/year: 5,149,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - convulsions or effect on seizure threshold
Skin and Appendages - hair
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year:
13,267,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - tremor
Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year:
18,28,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 14 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year:
7,83,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year:
7,83,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 27 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
20037) V.1- 1953- Volume(issue)/page/year: 18,189,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
Science Pub., 1969 Volume(issue)/page/year: 5,149,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 118 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada,
171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,333,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
Science Pub., 1969 Volume(issue)/page/year: 5,149,1976
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JEENAI Journal of Economic Entomology. (Entomological Soc. of America, 4603
Calvert Rd., College Park, MD 20740) V.1- 1908- Volume(issue)/page/year:
62,934,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
Science Pub., 1969 Volume(issue)/page/year: 5,149,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - quail
DOSE/DURATION : 57500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport
Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year:
9,563,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - domestic
DOSE/DURATION : 8 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
070944) V.1- 1973- Volume(issue)/page/year: 10,185,1981
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 71890 ug/kg/13W-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
35,101,1997
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 10 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
VEMJA8 Veterinary Medical Journal. (Cairo Univ., Faculty of Veterinary
Medicine, Giza, Egypt) V.1- 1953- Volume(issue)/page/year: 34,357,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 4 mg/kg
SEX/DURATION : male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological
Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986-
Volume(issue)/page/year: 2,142,1988
** MUTATION DATA **
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 6 mg/kg
REFERENCE :
ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der
Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep.
Ger.) V.29- 1974- Volume(issue)/page/year: 42,21,1987
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 84 mg/kg/1W (Continuous)
REFERENCE :
ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der
Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep.
Ger.) V.29- 1974- Volume(issue)/page/year: 42,21,1987
TYPE OF TEST : Micronucleus test
ROUTE OF EXPOSURE : Administration onto the skin
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 96 mg/kg/2W (Intermittent)
REFERENCE :
ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der
Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep.
Ger.) V.29- 1974- Volume(issue)/page/year: 42,21,1987
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 2 mg/L
REFERENCE :
ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der
Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep.
Ger.) V.29- 1974- Volume(issue)/page/year: 42,21,1987
TYPE OF TEST : Sister chromatid exchange
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 6 mg/kg
REFERENCE :
ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der
Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep.
Ger.) V.29- 1974- Volume(issue)/page/year: 42,21,1987
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION : 250 ug/L
REFERENCE :
ZNCBDA Zeitschrift fuer Naturforschung, Section C: Biosciences. (Verlag der
Zeitschrift fuer Naturforschung, Postfach 2645, D-7400 Tuebingen, Fed. Rep.
Ger.) V.29- 1974- Volume(issue)/page/year: 42,21,1987
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
*** STATUS IN U.S. ***
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
*** END OF RECORD ***