*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TD3500000
CHEMICAL NAME           : Phosphorodiamidic fluoride, N,N'-dibutyl-
CAS REGISTRY NUMBER     : 590-69-2
LAST UPDATED            : 199709
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C8-H20-F-N2-O-P
MOLECULAR WEIGHT        : 210.27
WISWESSER LINE NOTATION : 4MPO&FM4
SYNONYMS/TRADE NAMES :
   * Butafox
   * Di-(n-butylamino)fluorophosphine oxide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   11FYAN "Fluorine Chemistry, Volume III. Biological Effects of Organic
   Fluorides," Simons, J.H., ed., New York, Academic Press, Inc., 1963
   Volume(issue)/page/year: 3,71,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   15,1783,1966
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 180 ug/kg/36D-I
TOXIC EFFECTS :
   Spinal Cord - demyelination
   Peripheral Nerve and Sensation - structural change in nerve or sheath
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   15,1783,1966

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   CHREAY Chemical Reviews.  (American Chemical Soc., Distribution Office Dept.
   223, POB 57136, West End Stn., Washington, DC 20037)  V.1-    1924-
   Volume(issue)/page/year: 48,225,1951

 
                            *** END OF RECORD ***