*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TD5250000
CHEMICAL NAME           : Phosphorodithioic acid,
                          S-(((p-chlorophenyl)thio)methyl) O,O-diethyl ester
CAS REGISTRY NUMBER     : 786-19-6
BEILSTEIN REFERENCE NO. : 1885240
REFERENCE               : 4-06-00-01595 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 21
MOLECULAR FORMULA       : C11-H16-Cl-O2-P-S3
MOLECULAR WEIGHT        : 342.87
WISWESSER LINE NOTATION : 2OPS&O2&SR D1SPS&O2&O2
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acarithion
   * Akarithion
   * Carbofenothion
   * Carbophenothion
   * S-((p-Chlorophenylthio)methyl) O,O-diethyl phosphorodithioate
   * S-(4-Chlorophenylthiomethyl)diethyl phosphorothiolothionate
   * Dagadip
   * O,O-Diaethyl-S-((4-chlor-phenyl-thio)-methyl)dithiophosphat
   * O,O-Diethyl-S-((4-chloor-fenyl-thio)-methyl)-dithiofosfaat
   * O,O-Diethyl-S-p-chlorfenylthiomethylester kyseliny dithiofosforecne
   * O,O-Diethyl p-chlorophenylmercaptomethyl dithiophosphate
   * O,O-Diethyl S-p-chlorophenylthiomethyl dithiophosphate
   * O,O-Diethyl S-(4-chlorophenylthiomethyl) dithiophosphate
   * O,O-Diethyl S-(p-chlorophenylthiomethyl) phosphorodithioate
   * O,O-Diethyl dithiophosphoric acid p-chlorophenylthiomethyl ester
   * O,O-Dietil-S-((4-cloro-fenil-tio)-metile)-ditiofosfato
   * Dithiophosphate de O,O-diethyle et de (4-chloro-phenyl) thiomethyle
   * Endyl
   * ENT 23,708
   * Garrathion
   * Karbofenothion
   * Lethox
   * Nephocarp
   * Oleoakarithion
   * OMS 244
   * R-1303
   * Stauffer R-1,303
   * Trithion
   * Trithion miticide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMCHA2 Farm Chemicals Handbook.  (Meister Pub., 37841 Euclid Ave.,
   Willoughy, OH 44094)  Volume(issue)/page/year: -,C315,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   2,88,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APCRAW Advances in Pest Control Research.  (New York, NY)  V.1-18, 1957-68.
   Volume(issue)/page/year: 4,117,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 218 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARSIM* Agricultural Research Service, USDA Information Memorandum.
   (Beltsville, MD 20705)  Volume(issue)/page/year: 20,6,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 129,699,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SPEADM Special Publication of the Entomological Society of America.  (4603
   Calvert Rd., College Park, MD 20740)  Volume(issue)/page/year: 78-1,40,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1270 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCOC** Pesticide Chemicals Official Compendium, Association of the American
   Pesticide Control Officials, Inc., 1966.  (Topeka, KS)
   Volume(issue)/page/year: -,200,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 34800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSSCBG Pesticide Science.  (Blackwell Scientific Pub. Ltd., POB 88, Oxford,
   UK)  V.1-    1970-  Volume(issue)/page/year: 6,245,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 57200 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   11,,49,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 640 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - food intake (animal)
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   12,1377,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - quail
DOSE/DURATION           : 56800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSSCBG Pesticide Science.  (Blackwell Scientific Pub. Ltd., POB 88, Oxford,
   UK)  V.1-    1970-  Volume(issue)/page/year: 6,245,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - domestic
DOSE/DURATION           : 14 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EESADV Ecotoxicology and Environmental Safety.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1977-  Volume(issue)/page/year:
   2,151,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 5600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   21,315,1972
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7 mg/kg/4W-C
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
   Related to Chronic Data - death
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,500,1961
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 630 mg/kg/7D-C
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - other esterases
REFERENCE :
   PCBPBS Pesticide Biochemistry and Physiology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1971-  Volume(issue)/page/year:
   18,49,1982
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 20 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 102,89,1982

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   AQMOAC Air Quality Monographs.  (Washington, DC)  No.69-1 - No.75-25,
   1969-75(?).  Discontinued.  Volume(issue)/page/year: #73-19,1973

   TOXICOLOGY REVIEW
   RREVAH Residue Reviews.  (Springer-Verlag New York, Inc., Service Center, 44
   Hartz Way, Secaucus, NJ 07094)  V.1-    1962-  Volume(issue)/page/year:
   46,1,1973

   TOXICOLOGY REVIEW
   RREVAH Residue Reviews.  (Springer-Verlag New York, Inc., Service Center, 44
   Hartz Way, Secaucus, NJ 07094)  V.1-    1962-  Volume(issue)/page/year:
   63,1,1976

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
   FEREAC Federal Register.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402) V.1-    1936-  Volume(issue)/page/year:
   54,7740,1989

                          *** STATUS IN U.S. ***
 
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***