*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TF8225000
CHEMICAL NAME           : Phosphorothioic acid, O,O-dimethyl ester, S-ester
                          with 2-(mercaptomethyl)-5-methoxy- 4H-pyran-4-one
CAS REGISTRY NUMBER     : 2778-04-3
BEILSTEIN REFERENCE NO. : 0252435
REFERENCE               : 4-18-00-01160 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C9-H13-O6-P-S
MOLECULAR WEIGHT        : 280.25
WISWESSER LINE NOTATION : T6O DVJ B1SPO&O1&O1 EO1
COMPOUND DESCRIPTOR     : Agricultural Chemical
SYNONYMS/TRADE NAMES :
   * AC-18,737
   * O,O-Dimethyl S-(5-methoxy-4-oxo-4H-pyran-2-yl)phosphorothioate
   * O,O-Dimethyl-S-((5-methoxy-pyron-2-yl)-methyl)-thiolphosphat
   * O,O-Dimethyl S-(5-methoxypyronyl-2-methyl) thiophosphate
   * Endocid
   * Endocide
   * Endothion
   * ENT 24,653
   * Exothion
   * FMC 5767
   * 5-Methoxy-2-(dimethoxyphosphinylthiomethyl)pyrone-4
   * S-5-Methoxy-4-oxopyran-2-ylmethyl dimethyl phosphorothioate
   * S-((5-Methoxy-4H-pyron-2-yl)-methyl)-O,O-dimethyl-monothiofosfaat
   * S-((5-Methoxy-4H-pyron-2-yl)-methyl)-O,O-dimethyl-monothiophosphat
   * S-(5-Methoxy-4-pyron-2-ylmethyl) dimethyl phosphorothiolate
   * S-((5-Metossi-4H-piron-2-IL)-metil)-O,O-dimetil-monotiofosfato
   * NIA-5767
   * Niagara 5767
   * Phosphate 100
   * Phosphopyron
   * Phosphopyrone
   * 7175 RP
   * Thiophosphate de O,O-dimethyle et de S-((5-methoxy-4-pyronyl)-methyle)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   WRPCA2 World Review of Pest Control.  (London, UK)  V.1-10, 1962-71.
   Discontinued.  Volume(issue)/page/year: 9,119,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHJOAV Pharmaceutical Journal.  (Pharmaceutical Soc. of Great Britain, 1
   Lambeth High St., London, SE1 7JN, UK)  V.131-    1933-
   Volume(issue)/page/year: 185,361,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
   New York, Inc., 1971  Volume(issue)/page/year: -,343,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARSIM* Agricultural Research Service, USDA Information Memorandum.
   (Beltsville, MD 20705)  Volume(issue)/page/year: 20,10,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCOC** Pesticide Chemicals Official Compendium, Association of the American
   Pesticide Control Officials, Inc., 1966.  (Topeka, KS)
   Volume(issue)/page/year: -,473,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 88600 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   11,49,1967

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   DTTIAF Deutsche Tieraerztliche Wochenschrift.  (Hanover, Fed. Rep. Ger.)
   V.1-77, 1893-1970.  Volume(issue)/page/year: 80,485,1973

 
                            *** END OF RECORD ***