*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TH4897000
CHEMICAL NAME           : Phosphoryl chloride
CAS REGISTRY NUMBER     : 10025-87-3
LAST UPDATED            : 199806
DATA ITEMS CITED        : 25
MOLECULAR FORMULA       : Cl3-O-P
MOLECULAR WEIGHT        : 153.32
WISWESSER LINE NOTATION :  P  O G3
SYNONYMS/TRADE NAMES :
   * Fosforoxychlorid
   * Oxychlorid fosforecny
   * Phosphorus oxychloride
   * Phosphorus oxytrichloride
   * Phosphoryl trichloride
   * Trichlorophosphine oxide
   * Trichlorophosphorus oxide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 36 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Liver - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0534840
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 32 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku,"
   Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu
   Praha, Czechoslovakia, 1972  Volume(issue)/page/year: -,17,1972
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Liver - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0534840
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 53 ppm/4H
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - irritability
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   25,470,1964
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 1340 ug/m3/17W-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - structural or functional change in trachea
   or bronchi
   Musculoskeletal - osteoporosis
   Immunological Including Allergic - other immediate (humoral): urticaria,
   allergic rhinitis, serum sickness
REFERENCE :
   JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology.
   (Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia)  V.1-
   1957-  Volume(issue)/page/year: 21,387,1977

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 0.63 mg/m3 (0.1 ppm)
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-AUSTRALIA:TWA 0.1 ppm (0.6 mg/m3);STEL 0.5 ppm (3 mg/m3) JAN 1993
   
   OEL-BELGIUM:TWA 0.1 ppm (0.63 mg/m3);STEL 0.5 ppm (3.1 mg/m3) JAN 1993
   
   OEL-DENMARK:TWA 0.1 ppm (0.6 mg/m3) JAN 1993
   
   OEL-FINLAND:STEL 0.5 ppm (3 mg/m3);Skin JAN 1993
   
   OEL-FRANCE:TWA 0.1 ppm (0.6 mg/m3) JAN 1993
   
   OEL-GERMANY:TWA 0.2 ppm (1 mg/m3) JAN 1993
   
   OEL-THE NETHERLANDS:TWA 0.1 ppm (0.6 mg/m3) JAN 1993
   
   OEL-RUSSIA:STEL 0.05 mg/m3;Skin JAN 1993
   
   OEL-SWITZERLAND:TWA 0.1 ppm (0.6 mg/m3);STEL 0.2 ppm (1.2 mg/m3) JAN 1993
   
   OEL-TURKEY:TWA 0.5 ppm (3 mg/m3) JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.2 ppm (1.2 mg/m3);STEL 0.6 ppm JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO PHOSPHORUS OXYCHLORIDE-air:10H TWA 0.1 ppm;STEL 0.5 ppm
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 81931
       No. of Facilities: 155 (estimated)
       No. of Industries: 7
       No. of Occupations: 22
       No. of Employees: 7258 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 81931
       No. of Facilities: 165 (estimated)
       No. of Industries: 9
       No. of Occupations: 29
       No. of Employees: 12587 (estimated)
       No. of Female Employees: 2945 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***