*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TH8849900
CHEMICAL NAME           : Phthalazine, 1,4-dihydrazino-
CAS REGISTRY NUMBER     : 484-23-1
BEILSTEIN REFERENCE NO. : 0183442
REFERENCE               : 5-25-17-00465 (Beilstein Handbook Reference)
LAST UPDATED            : 199703
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C8-H10-N6
MOLECULAR WEIGHT        : 190.24
WISWESSER LINE NOTATION : T66 CNNJ BMZ EMZ
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * C 7441
   * Cassella 532
   * Dihydralazin
   * Dihydralazine
   * Dihydrallazin
   * 1,4-Dihydrazinonaphthalazine
   * Dihydrazinophthalazine
   * 1,4-Dihydrazinophthalazine
   * 2,3-Dihydro-1,4-phthalazinedione dihydrazone
   * Hypopresol
   * Nepresol
   * Nepresolin
   * Nepressol
   * Ophthazin
   * 1,4-Phthalazinedione, 2,3-dihydro-, dihydrazone
   * Tonolysin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 106 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4376771
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 11,107,1976
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE                    : 250 ug/kg
SEX/DURATION            : female 32 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   OBGNAS Obstetrics and Gynecology.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1953- Volume(issue)/page/year:
   55,519,1980
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 250 ug/plate
REFERENCE :
   ABPLAF Acta Biochimica Polonica.  (Polish Biochemical Society, Posteura 3,
   01-093 Warsaw, Poland) V.1-    1954-  Volume(issue)/page/year: 42,291,1995
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 125 ug/tube
REFERENCE :
   ABPLAF Acta Biochimica Polonica.  (Polish Biochemical Society, Posteura 3,
   01-093 Warsaw, Poland) V.1-    1954-  Volume(issue)/page/year: 42,291,1995
 
                            *** END OF RECORD ***