*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TI3150000
CHEMICAL NAME           : Phthalic anhydride
CAS REGISTRY NUMBER     : 85-44-9
LAST UPDATED            : 199712
DATA ITEMS CITED        : 48
MOLECULAR FORMULA       : C8-H4-O3
MOLECULAR WEIGHT        : 148.12
WISWESSER LINE NOTATION : T56 BVOVJ
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Reproductive Effector
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Anhydride phtalique
   * Anhydrid kyseliny ftalove
   * Anidride ftalica
   * 1,2-Benzenedicarboxylic acid anhydride
   * 1,3-Dioxophthalan
   * ESEN
   * Ftaalzuuranhydride
   * Ftalanhydrid
   * Ftalowy bezwodnik
   * Isobenzofuran, 1,3-dihydro-1,3-dioxo-
   * 1,3-Isobenzofurandione
   * NCI-C03601
   * Phthalandione
   * 1,3-Phthalandione
   * Phthalic acid anhydride
   * Phthalic anhydride
   * Phthalsaeureanhydrid
   * RCRA waste number U190
   * Retarder AK
   * Retarder PD
   * Vulkalent B
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/24H
REACTION SEVERITY       : Mild
REFERENCE :
   BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets.  (1810
   Frontage Rd., Northbrook, IL 60062)  Volume(issue)/page/year: 13-4/1970
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 50 mg/24H/MOD
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 15(Suppl 1),S68,1996
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1530 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 15(Suppl 1),S68,1996
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >210 mg/m3/1H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets.  (1810
   Frontage Rd., Northbrook, IL 60062)  Volume(issue)/page/year: 13-4/1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,100,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,322,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets.  (1810
   Frontage Rd., Northbrook, IL 60062)  Volume(issue)/page/year: 13-4/1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZWAE "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH,
   Chemical Rubber Co., 1968  Volume(issue)/page/year: -,410,1968
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/m3/2H/2W-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - structural or functional change in trachea
   or bronchi
   Liver - other changes
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 2,59,1961
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 6 gm/kg/42D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Gastrointestinal - gastritis
   Gastrointestinal - other changes
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 2,59,1961
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 mg/m3
SEX/DURATION            : male 45 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 35(1),105,1970
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 203 mg/kg
SEX/DURATION            : female 8-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   2,61,1982
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 3 mmol/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   24,181,1994

                              *** REVIEWS ***
 
   ACGIH TLV-Not classifiable as a human carcinogen
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

   ACGIH TLV-TWA 6.1 mg/m3 (1 ppm)
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

   TOXICOLOGY REVIEW
   BPCT** Progress Report from the Environmental Protection Agency to NIOSH on
   Benzenepolycarboxylates, 1974  Volume(issue)/page/year: -,183,1974

   TOXICOLOGY REVIEW
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 4,3,1973

   TOXICOLOGY REVIEW
   CMTVAS Cahiers de Medecine du Travail.  (Association Professionnelle Belge
   des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium)  V.1- 1963-
    Volume(issue)/page/year: 10(3),49,1973

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 2 ppm (12 mg/m3)
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   3,212,1971

   OSHA PEL (Gen Indu):8H TWA 2 ppm (12 mg/m3)
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Construc):8H TWA 2 ppm (12 mg/m3)
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

   OSHA PEL (Shipyard):8H TWA 2 ppm (12 mg/m3)
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1915.1000,1993

   OSHA PEL (Fed Cont):8H TWA 2 ppm (12 mg/m3)
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   41,50-204.50,1994

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-AUSTRALIA:TWA 1 ppm (6 mg/m3) JAN 1993
   
   OEL-BELGIUM:TWA 1 ppm (6.1 mg/m3) JAN 1993
   
   OEL-DENMARK:TWA 5 mg/m3 JAN 1993
   
   OEL-FINLAND:TWA 2 mg/m3;STEL 3 mg/m3;Skin JAN 1993
   
   OEL-FRANCE:STEL 6 mg/m3 JAN 1993
   
   OEL-GERMANY:TWA 5 mg/m3 JAN 1993
   
   OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993
   
   OEL-THE NETHERLANDS:TWA 1 ppm (6 mg/m3) JAN 1993
   
   OEL-THE PHILIPPINES:TWA 2 ppm (12 mg/m3) JAN 1993
   
   OEL-POLAND:TWA 1 mg/m3 JAN 1993
   
   OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993
   
   OEL-SWEDEN:TWA 1 ppm (6 mg/m3);STEL 2 ppm (12 mg/m3) JAN 1993
   
   OEL-SWITZERLAND:TWA 0.8 ppm (5 mg/m3);STEL 1.6 ppm (10 mg/m3) JAN 1993
   
   OEL-UNITED KINGDOM:TWA 1 ppm (6 mg/m3);STEL 4 ppm (24 mg/m3) JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO PHTHALIC ANHYDRIDE-air:10H TWA 1 ppm
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 59230
       No. of Facilities: 10056 (estimated)
       No. of Industries: 128
       No. of Occupations: 90
       No. of Employees: 134716 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 59230
       No. of Facilities: 5265 (estimated)
       No. of Industries: 72
       No. of Occupations: 67
       No. of Employees: 81312 (estimated)
       No. of Female Employees: 14675 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   On EPA IRIS database
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-159,79

 
                            *** END OF RECORD ***