*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TI3450000 CHEMICAL NAME : Phthalic anhydride, tetrachloro- CAS REGISTRY NUMBER : 117-08-8 BEILSTEIN REFERENCE NO. : 0211560 REFERENCE : 5-17-11-00260 (Beilstein Handbook Reference) LAST UPDATED : 199712 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C8-Cl4-O3 MOLECULAR WEIGHT : 285.88 COMPOUND DESCRIPTOR : Tumorigen Primary Irritant SYNONYMS/TRADE NAMES : * CP 626 * 1,3-Isobenzofurandione, 4,5,6,7-tetrachloro- * NCI-C61585 * Niagathal * 4,5,6,7-Tetrachloro-1,3-isobenzofurandione * Tetrachlorophthalic anhydride * Tetrathal *** HEALTH HAZARD DATA *** ** SKIN/EYE IRRITATION DATA ** TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 100 mg REACTION SEVERITY : Mild REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3351 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >15800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3351 TYPE OF TEST : LC - Lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >3600 mg/m3/4H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3351 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3351 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 68250 mg/kg/13W-I TOXIC EFFECTS : Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-93-3351 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5 mg/m3/6H/13W-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - changes in lung weight Endocrine - hyperglycemia Blood - changes in leukocyte (WBC) count REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0538630 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3316 No. of Facilities: 55 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 142 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3316 No. of Facilities: 43 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 2067 (estimated) No. of Female Employees: 786 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8912 EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 NTP Toxicity studies, RPT# TOX-28, October 1997 *** END OF RECORD ***