*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TI5609700 CHEMICAL NAME : Phthalimide, N-(1-(morpholinomethyl)-2,6-dioxo-3-piperidyl)- CAS REGISTRY NUMBER : 10329-95-0 BEILSTEIN REFERENCE NO. : 1230262 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C18-H19-N3-O5 MOLECULAR WEIGHT : 357.40 WISWESSER LINE NOTATION : T56 BVNVJ C- DT6VNVTJ B1- AT6N DOTJ COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * CG 601 * E-298 * 1H-Isoindole-1,3(2H)-dione, 2-(1-(4-morpholinylmethyl)-2,6-dioxo-3-piperidinyl)- * 1-Methyl-morpholino-3-phthalimido-glutarimide * N-(1-(Morpholinomethyl)-2,6-dioxo-3-piperidyl)phthalimide * 1-Morpholinomethylthalidomide * Morpholino-thalidomide *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >8 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 194,39,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1300 mg/kg TOXIC EFFECTS : Endocrine - changes in luteinizing hormone Endocrine - other changes REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 194,39,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3 gm/kg TOXIC EFFECTS : Endocrine - changes in luteinizing hormone Endocrine - other changes REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 194,39,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 840 mg/kg TOXIC EFFECTS : Endocrine - changes in luteinizing hormone Endocrine - other changes REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 194,39,1971 *** END OF RECORD ***