*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TI8576000 CHEMICAL NAME : Phthalonitrile, 4-nitro- CAS REGISTRY NUMBER : 31643-49-9 LAST UPDATED : 199703 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C8-H3-N3-O2 MOLECULAR WEIGHT : 173.14 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * 1,2-Benzenedicarbonitrile, 4-nitro- * 3,4-Dicyanonitrobenzene * 4-Nitro-1,2-benzenedicarbonitrile * 4-Nitrophthalonitrile *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 850 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(9),92,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(9),92,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2550 mg/kg/30D-I TOXIC EFFECTS : Liver - hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, Bladder - proteinuria Blood - methemoglobinemia-carboxyhemoglobin REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(9),92,1987 *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***