*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TJ2360000
CHEMICAL NAME           : Physostigmine, methiodide
CAS REGISTRY NUMBER     : 6091-11-8
LAST UPDATED            : 199009
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C15-H21-N3-O2.C-H3-I
MOLECULAR WEIGHT        : 417.33
WISWESSER LINE NOTATION : T B556 EN GNTT&J B1 E1 G1 KOVM1 &I1
SYNONYMS/TRADE NAMES :
   * AR-45
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 43,413,1931
 
TYPE OF TEST            : LD80 - Lethal Dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 ug/kg
TOXIC EFFECTS :
   Autonomic Nervous System - other (direct) parasympathomimetic
   Behavioral - coma
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB158-508
 
                            *** END OF RECORD ***