*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TJ5363000 CHEMICAL NAME : 4-Picoline, 2-amino-, hydrochloride CAS REGISTRY NUMBER : 32654-41-4 LAST UPDATED : 199606 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C6-H8-N2.xCl-H MOLECULAR WEIGHT : 363.38 WISWESSER LINE NOTATION : T6NJ BZ D1 &GH COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * Ascensil hydrochloride * 4M2AP hydrochloride * 4-Methyl-2-pyridinamine hydrochloride * 2-Pyridinamine, 4-methyl-, hydrochloride * RA 1226 hydrochloride * VMI 20-4 * W 45 hydrochloride * W 45 Raschig hydrochloride *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FMTYA2 Farmatsiya (Sofia). (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1951- Volume(issue)/page/year: 23(5),65,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 210 mg/kg TOXIC EFFECTS : Vascular - BP elevation not characterized in autonomic section REFERENCE : PBFMAV Problemi na Farmatsiyata. Problems in Pharmacy. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1- 1973- Volume(issue)/page/year: 5,125,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 380 mg/kg TOXIC EFFECTS : Behavioral - excitement Behavioral - changes in motor activity (specific assay) REFERENCE : FMTYA2 Farmatsiya (Sofia). (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1951- Volume(issue)/page/year: 23(5),65,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 110 mg/kg TOXIC EFFECTS : Behavioral - excitement Behavioral - muscle contraction or spasticity REFERENCE : FMTYA2 Farmatsiya (Sofia). (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1951- Volume(issue)/page/year: 23(5),65,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 27 mg/kg TOXIC EFFECTS : Behavioral - excitement REFERENCE : FMTYA2 Farmatsiya (Sofia). (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1951- Volume(issue)/page/year: 23(5),65,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : >120 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FMTYA2 Farmatsiya (Sofia). (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1951- Volume(issue)/page/year: 23(5),65,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FMTYA2 Farmatsiya (Sofia). (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1951- Volume(issue)/page/year: 23(5),65,1973 *** END OF RECORD ***