*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TK6026900 CHEMICAL NAME : 4-Pipecoline, 1-nitroso- CAS REGISTRY NUMBER : 15104-03-7 BEILSTEIN REFERENCE NO. : 1342086 REFERENCE : 5-20-04-00140 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C6-H12-N2-O MOLECULAR WEIGHT : 128.20 WISWESSER LINE NOTATION : T6NTJ ANO D1 COMPOUND DESCRIPTOR : Tumorigen Mutagen SYNONYMS/TRADE NAMES : * 4-Methylnitrosopiperidine * 1-Nitroso-4-pipecoline *** HEALTH HAZARD DATA *** ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2016 mg/kg/40W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Gastrointestinal - tumors REFERENCE : IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966- Volume(issue)/page/year: 16,318,1975 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 200 ug/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 56,131,1977 TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 5 mmol/L/24H REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 67,27,1979 TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 25 mmol/L/24H REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 57,155,1978 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-forward mutation EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-partial sex chrom. loss *** END OF RECORD ***