*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TK7850000
CHEMICAL NAME           : 1-Piperazineacetamide,
                          N-isopropyl-4-(3,4,5-trimethoxycinnamoyl)-, maleate
CAS REGISTRY NUMBER     : 26328-00-7
LAST UPDATED            : 198706
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C21-H31-N3-O5.C4-H4-O4
MOLECULAR WEIGHT        : 521.63
WISWESSER LINE NOTATION : T6N DNTJ AV1U1R CO1 DO1 EO1& D1VMY1&1 &QV1U1QV -C
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N-Isopropyl-4-(3,4,5-trimethoxycinnamoyl)-1-piperazineacetamide maleate
   * Maleate de cinpropazide
   * 68111 M.D.
   * (3',4',5'-Trimethoxycinnamoyl)-1-(N-isopropyl amino carbonyl methyl)-4  
   piperazine maleate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1295 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 29,233,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHTPBA Chimica Therapeutica.  (Paris, France)  V.1-8, 1965-73.  For
   publisher information, see EJMCA5.  Volume(issue)/page/year: 4,293,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 475 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 29,233,1974
 
                            *** END OF RECORD ***