*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TH9625000
CHEMICAL NAME           : Phthalic acid
CAS REGISTRY NUMBER     : 88-99-3
BEILSTEIN REFERENCE NO. : 0608199
REFERENCE               : 4-09-00-03167 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C8-H6-O4
MOLECULAR WEIGHT        : 166.14
WISWESSER LINE NOTATION : QVR BVQ
SYNONYMS/TRADE NAMES :
   * Acide phtalique
   * Benzene-1,2-dicarboxylic acid
   * o-Benzenedicarboxylic acid
   * 1,2-Benzenedicarboxylic acid
   * o-Dicarboxybenzene
   * Kyselina ftalova
   * O-Phthalic acid
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 32(8),12,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2530 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,711,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 550 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 49,471,1942
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 102 mg/kg/26W-I
TOXIC EFFECTS :
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 32(8),12,1967

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   BPCT** Progress Report from the Environmental Protection Agency to NIOSH on
   Benzenepolycarboxylates, 1974  Volume(issue)/page/year: -,183,1974

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 59185
       No. of Facilities: 106 (estimated)
       No. of Industries: 4
       No. of Occupations: 8
       No. of Employees: 2321 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 59185
       No. of Facilities: 1480 (estimated)
       No. of Industries: 22
       No. of Occupations: 27
       No. of Employees: 19693 (estimated)
       No. of Female Employees: 2861 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***