*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TK7910000
CHEMICAL NAME           : 1-Piperazineaceto-2',6'-xylidide,
                          4-(4,4-bis(p-fluorophenyl)butyl)-
CAS REGISTRY NUMBER     : 3416-26-0
BEILSTEIN REFERENCE NO. : 0904339
REFERENCE               : 5-23-02-00297 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C30-H35-F2-N3-O
MOLECULAR WEIGHT        : 491.68
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   *   1-(4,4-Bis(4-fluorofenil)butil)-4-((2,6-dimetilanilinocarbonil)metil)pip
     erazina
   * 4-(4,4-Bis(p-fluorophenyl)butyl)-1-piperazineaceto-2',6'-xylidide
   * Clinium
   * Corflazine
   * Klinium
   * Lidoflazin
   * Lidoflazina
   * Lidoflazine
   * Lidoflazinum
   * McN-JR 7904
   * Ordiflazine
   * 1-Piperazineacetamide,  
   4-(4,4-bis(4-fluorophenyl)butyl)-N-(2,6-dimethylphenyl)-
   * R 7904
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 20570 ug/kg/8D-I
TOXIC EFFECTS :
   Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 22,923,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 32,461,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 32,461,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARPMAS Archiv der Pharmazie (Weinheim, Germany)  (VCH Pub., Inc., 303 NW
   12th Ave., Deerfield Beach, FL 33441)  V.51-261, 1835-1923; V.305-    1972-
   Volume(issue)/page/year: 322,359,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRXXBL French Demande Patent Document.  (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #2279383
 
                            *** END OF RECORD ***