*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TK8220100
CHEMICAL NAME           : Piperazine,
                          1-(1,3-benzodioxol-5-ylmethyl)-4-((4-chlorophenoxy)ac
                          etyl)-, monohydrochloride
CAS REGISTRY NUMBER     : 34161-23-4
LAST UPDATED            : 199009
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C20-H21-Cl-N2-O4.Cl-H
MOLECULAR WEIGHT        : 425.34
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Attentil
   * 1-(1,3-Benzodioxol-5-ylmethyl)-4-((4-chlorophenoxy)acetyl)piperazine  
   hydrochloride
   * BP 662
   * Fipexide hydrochloride
   * Fipexidum hydrochloride
   * Piperazine, 1-((p-chlorophenoxy)acetyl)-4-piperonyl-, monohydrochloride
   * Vigilor
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4482 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   ACTTDZ Acta Therapeutica.  (Pl. de Bastogne 8, B13, 1080 Brussels, Belgium)
   V.1-    1975-  Volume(issue)/page/year: 11,387,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   ACTTDZ Acta Therapeutica.  (Pl. de Bastogne 8, B13, 1080 Brussels, Belgium)
   V.1-    1975-  Volume(issue)/page/year: 11,387,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4150 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   ACTTDZ Acta Therapeutica.  (Pl. de Bastogne 8, B13, 1080 Brussels, Belgium)
   V.1-    1975-  Volume(issue)/page/year: 11,387,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 499 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   ACTTDZ Acta Therapeutica.  (Pl. de Bastogne 8, B13, 1080 Brussels, Belgium)
   V.1-    1975-  Volume(issue)/page/year: 11,387,1985
 
                            *** END OF RECORD ***