*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TK8230000
CHEMICAL NAME           : Piperazine, 4-benzoyl-3,5-dimethyl-1-nitroso-
CAS REGISTRY NUMBER     : 61034-40-0
LAST UPDATED            : 199410
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C13-H18-N3-O2
MOLECULAR WEIGHT        : 248.34
WISWESSER LINE NOTATION : T6N DNTJ AVR& B1 DNO F1
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 1-Benzoyl-2,6-dimethyl-4-nitrosopiperazine
   * 4-Benzoyl-3,5-dimethyl-N-nitrosopiperazine
   * N-Nitroso-4-benzoyl-3,5-dimethylpiperazine
   * 1-Nitroso-4-benzoyl-3,5-dimethylpiperazine
   * Piperazine, 1-benzoyl-2,6-dimethyl-4-nitroso-
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4300 mg/kg/50W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Gastrointestinal - tumors
   Liver - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,1034,1981
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 250 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 111,135,1983

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test

 
                            *** END OF RECORD ***