*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TK8720000
CHEMICAL NAME           : Piperazine,
                          1,4-bis(bis(1-aziridinyl)phosphinothioyl)-
CAS REGISTRY NUMBER     : 1950-08-9
BEILSTEIN REFERENCE NO. : 0629376
REFERENCE               : 5-23-03-00231 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C12-H24-N6-P2-S2
MOLECULAR WEIGHT        : 378.48
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1,4-Bis(bis(1-aziridinyl)phosphinothioyl)piperazine
   * Phosphine sulfide, 1,4-piperazinediylbis(bis(1-aziridinyl)-
   * Thiodipine
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg/10D-I
TOXIC EFFECTS :
   Endocrine - changes in spleen weight
   Endocrine - changes in thymus weight
   Related to Chronic Data - death
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 24,732,1961
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg/10D-I
TOXIC EFFECTS :
   Blood - leukopenia
   Related to Chronic Data - death
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 24,732,1961
 
                            *** END OF RECORD ***