*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TK8750000
CHEMICAL NAME           : Piperazine, 1,4-bis(1,4-benzodioxan-2-ylmethyl)-
CAS REGISTRY NUMBER     : 7762-32-5
LAST UPDATED            : 199012
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C22-H26-N2-O4
MOLECULAR WEIGHT        : 382.50
WISWESSER LINE NOTATION : T66 BO EOJ C1- AT6N DNTJ D1- CT66 BO EOJ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1,4-Bis(1,4-benzodioxan-2-yl-methyl)piperazine
   * Dibozane
   * McN-181
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMPCAS Journal of Medicinal and Pharmaceutical Chemistry.  (Washington, DC)
   V.1-5, 1959-62.  For publisher information, see JMCMAR.
   Volume(issue)/page/year: 5,1285,1962
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 12,355,1953
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 43 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 12,355,1953
 
                            *** END OF RECORD ***