*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : TL1225000
CHEMICAL NAME : 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-,
citrate (1:1)
CAS REGISTRY NUMBER : 1642-54-2
LAST UPDATED : 199707
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C10-H21-N3-O.C6-H8-O7
MOLECULAR WEIGHT : 391.48
WISWESSER LINE NOTATION : T6N DNTJ AVN2&2 D1 &OV1XQVO&1VO
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Banocide
* Carricide citrate
* Caritrol
* Dicarocide
* Diethylcarbamazane citrate
* Diethylcarbamazine acid citrate
* Diethylcarbamazine citrate
* Diethylcarbamazine hydrogen citrate
* 1-Diethylcarbamoyl-4-methylpiperazine dihydrogen citrate
* N,N-Diethyl-4-methyl-1-piperazine carboxamide citrate
* N,N-Diethyl-4-methyl-1-piperazinecarboxamide dihydrogen citrate (1:1)
* Ditrazin citrate
* Ditrazine citrate
* Ethodryl citrate
* Filazine
* Franocide
* Franozan
* Hetrazan
* Loxuran
* 1-Methyl-4-diethylcarbamoylpiperazine citrate
* 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-,
2-hydroxy-1,2,3-propanetricarboxylate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research.
(Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way,
Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 309 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,63,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1136 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,306,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 660 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,41,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 425 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJSBDB Indian Journal of Chemistry, Section B: Organic Chemistry, Including
Medicinal Chemistry. (Publications & Information Directorate, Council of
Scientific and Industrial Research (CSIR), Hillside Rd., New Delhi 110 012,
India) V.14B- 1976- Volume(issue)/page/year: 26,748,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 608 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,306,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
Volume(issue)/page/year: NX#00466
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 14 mg/kg/7D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - changes in sodium
Nutritional and Gross Metabolic - changes in calcium
Nutritional and Gross Metabolic - changes in phosphorus
REFERENCE :
BIOKE3 Biokemistri. (Klobex Academic Publishers, POB 4216, Ilorin, Nigiria)
V.1- 1994- Volume(issue)/page/year: 5,125,1995
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1800 mg/kg
SEX/DURATION : female 8-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
Volume(issue)/page/year: 60,1529,1972
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X1545
No. of Facilities: 611 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 5223 (estimated)
No. of Female Employees: 2464 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***