*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL1570000
CHEMICAL NAME           : Piperazine,
                          1-(8-chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)-4
                          -methyl-
CAS REGISTRY NUMBER     : 13448-22-1
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H21-Cl-N2-S
MOLECULAR WEIGHT        : 344.93
WISWESSER LINE NOTATION : T C676 BS&T&J FG I- AT6N DNTJ D1
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 1-(8-Chloro-10,11-dihydrodibenzo(b,f)thiepin-10-yl)-4-methylpiperazine
   * Clorotepine
   * Clotepin
   * Clothepin
   * Octoclothepin
   * Octoclothepine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 78 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 48,144,1983
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1080 mg/kg
SEX/DURATION            : female 2-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 22,1429,1967
 
                            *** END OF RECORD ***