*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL1890000
CHEMICAL NAME           : Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-,
                          dihydrochloride
CAS REGISTRY NUMBER     : 1031-92-1
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C17-H18-Cl-N2.2Cl-H
MOLECULAR WEIGHT        : 358.74
WISWESSER LINE NOTATION : T6M DNTJ DYR&R DG &GH 2
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * N-(p-Chlorobenzhydryl)piperazine dihydrochloride
   * 1-(4-Chlorobenzhydryl)piperazine dihydrochloride
   * N-(4-Chlorobenzhydryl)piperazine dihydrochloride
   * 1-(p-Chloro-alpha-phenylbenzyl)piperazine dihydrochloride
   * Norchlorcyclizine dihydrochloride
   * Piperazine, 1-((4-chlorophenyl)phenylmethyl)-, dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 120 mg/kg
SEX/DURATION            : female 13-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   17,67,1970
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/kg
SEX/DURATION            : female 12-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 155,494,1967
 
                            *** END OF RECORD ***