*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL2803000
CHEMICAL NAME           : Piperazine,
                          1-(o-chlorophenyl)-4-(3,4-dimethoxyphenethyl)-
CAS REGISTRY NUMBER     : 1243-33-0
BEILSTEIN REFERENCE NO. : 0627902
REFERENCE               : 5-23-02-00160 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H25-Cl-N2-O2
MOLECULAR WEIGHT        : 360.92
WISWESSER LINE NOTATION : T6N DNTJ A2R CO1 DO1& DR CG
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1-o-Chlorophenyl-4-(3,4-dimethoxyphenethyl)piperazine
   * 1-(2-Chlorphenyl)-4-(3,4-dimethoxyphenethyl)piperazine
   * Mefeclorazine
   * Mepheclorazin
   * N-(Dimethoxy-3,4-phenethyl),-N'-(chloro-2-phenyl) piperazine
   * SD 218-06
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSCBAY Psychopharmacology Service Center, Bulletin.  (Bethesda, MD)  V.1-3,
   1961-65.  For publisher information, see PSYBB9.  Volume(issue)/page/year:
   2,17,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - central sympatholytic
   Vascular - BP elevation not characterized in autonomic section
   Lungs, Thorax, or Respiration - bronchiolar dilation
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 8,104,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 133,29,1961
 
                            *** END OF RECORD ***