*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL4025000
CHEMICAL NAME           : Piperazine, dihydrochloride
CAS REGISTRY NUMBER     : 142-64-3
LAST UPDATED            : 199712
DATA ITEMS CITED        : 18
MOLECULAR FORMULA       : C4-H10-N2.2Cl-H
MOLECULAR WEIGHT        : 159.08
WISWESSER LINE NOTATION : T6M DMTJ &GH 2
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Diethylenediamine dihydrochloride
   * Dihydrochloride salt of diethylenediamine
   * Dihydro Pip Wormer
   * Dowzene DHC
   * Piperazine dihydrochloride
   * Piperazine hydrochloride
   * Piperazine wormer premix
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GUCHAZ Guide to the Chemicals Used in Crop Protection.  (Information Canada,
   171 Slater St., Ottawa, Ont., Canada)  Volume(issue)/page/year: 6,416,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1970 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 17,475,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2030 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 4,649,1954

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 5 mg/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   OSHA PEL (Construc):skin
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-AUSTRALIA:TWA 5 mg/m3 JAN 1993
   
   OEL-BELGIUM:TWA 5 mg/m3 JAN 1993
   
   OEL-DENMARK:TWA 5 mg/m3 JAN 1993
   
   OEL-FRANCE:TWA 5 mg/m3 JAN 1993
   
   OEL-SWITZERLAND:TWA 5 mg/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 5 mg/m3 JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO PIPERAZINE-air:10H TWA 5.0 mg/m3
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 80559
       No. of Facilities: 68 (estimated)
       No. of Industries: 1
       No. of Occupations: 5
       No. of Employees: 1284 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 80559
       No. of Facilities: 163 (estimated)
       No. of Industries: 1
       No. of Occupations: 12
       No. of Employees: 5730 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***