*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TL4240000 CHEMICAL NAME : Piperazine, 1-(10,11-dihydro-8-fluorodibenzo(b,f)thiepin-10-yl)-4 -methyl-, maleate (1:1) CAS REGISTRY NUMBER : 19939-33-4 LAST UPDATED : 198707 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C19-H21-F-N2-S.C4-H4-O4 MOLECULAR WEIGHT : 444.56 WISWESSER LINE NOTATION : T C676 BS&T&J FF I- AT6N DNTJ D1 &QV1U1VQ -C COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * Dibenzo(b,f)thiepin, 10,11-dihydro-8-fluoro-10-(4-methylpiperazino)-, hydrogen maleate * 8-Fluoro-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin maleate * Fluothepin maleate * VUFB6.271 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 138 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - paresthesis Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity REFERENCE : CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 41,881,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 42 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : ACNSAX Activitas Nervosa Superior. (Avicenum, Malostranske nam. 28, Prague 1, Czechoslovakia) V.1- 1959- Volume(issue)/page/year: 9,422,1967 *** END OF RECORD ***