*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL4325000
CHEMICAL NAME           : Piperazine,
                          1-(10,11-dihydro-8-methylthiodibenzo(b,f)thiepin-10-y
                          l)-4-methyl-, maleate (1:1)
CAS REGISTRY NUMBER     : 19728-88-2
LAST UPDATED            : 198706
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C20-H24-N2-S2.C4-H4-O4
MOLECULAR WEIGHT        : 472.66
WISWESSER LINE NOTATION : T C676 BS&T&J FS1 I- AT6N DNTJ D1 &QV1U1VQ -C
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Dibenzo(b,f)thiepin, 10,11-dihydro-8-methylthio-10-(4-methylpiperazino)-, 
    hydrogen maleate
   * Dibenzo(b,f)thiepin, 10,11-dihydro-10-(4-methylpiperazino)-8-methylthio-, 
    hydrogen maleate
   *   1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpipera
     zine maleate
   * Methiothepin maleate
   * 8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin  
   maleate
   * Metitepin maleate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 39,3338,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 67600 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 39,3153,1974
 
                            *** END OF RECORD ***