*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL6400700
CHEMICAL NAME           : 2,6-Piperazinedione,
                          4,4'-propylidenebis(1-(morpholinomethyl)-, (+-)-
CAS REGISTRY NUMBER     : 95604-83-4
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C21-H34-N6-O6
MOLECULAR WEIGHT        : 466.61
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * AT-2153
   * dl-1,2-Bis(4-morpholinomethyl-3,5-dioxopiperazin-1-yl)propane
   * MST-02
   * Probimane
   * (+-)-4,4'-Propylidenebis(1-(morpholinomethyl)-2,6-piperazinedione)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 376 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   8,369,1987
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 896 mg/kg/8D-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   8,369,1987
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1320 mg/kg/8D-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   8,369,1987
 
                            *** END OF RECORD ***