*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL6475000
CHEMICAL NAME           : Piperazine, 1-(diphenylmethyl)-4-methyl-
CAS REGISTRY NUMBER     : 82-92-8
BEILSTEIN REFERENCE NO. : 0230441
REFERENCE               : 5-23-01-00232 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C18-H22-N2
MOLECULAR WEIGHT        : 266.42
WISWESSER LINE NOTATION : T6N DNTJ AYR&R& D1
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * (N-Benzhydryl)(N'-methyl)diethylenediamine
   * N-Benzhydryl-N-methyl piperazine
   * BW 47-83
   * Compound 47-83
   * Ciclizina
   * Cyclizine
   * 1-Diphenylmethyl-4-methylpiperazine
   * Marazine
   * Marezine
   * Marzine
   * N-Methyl-N'-benzyhydrylpiperazine
   * Nautazine
   * Neo-devomit
   * Valoid
   * Wellcome preparation 47-83
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 126 mg/kg/6W-I
TOXIC EFFECTS :
   Blood - agranulocytosis
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   292,174,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 147 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,218,1972
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 450 mg/kg
SEX/DURATION            : female 10-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   109,323,1970
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 450 mg/kg
SEX/DURATION            : female 10-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - homeostasis
   Reproductive - Effects on Newborn - stillbirth
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   109,323,1970

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   ADVPA3 Advances in Pharmacology.  (New York, NY)  V.1-6, 1962-68.  For
   publisher information, see AVPCAQ.  Volume(issue)/page/year: 4,263,1966

 
                            *** END OF RECORD ***