*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL6490000
CHEMICAL NAME           : Piperazine, 1-diphenylmethyl-4-methyl-,
                          dihydrochloride
CAS REGISTRY NUMBER     : 5897-18-7
LAST UPDATED            : 199606
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C18-H22-N2.2Cl-H
MOLECULAR WEIGHT        : 339.34
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Cyclizine dihydrochloride
   * 1-Diphenylmethyl-4-methylpiperazine dihydrochloride
   * Piperazine, 1-benzhydryl-4-methyl-, dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 69 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 46,279,1957
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11928 mg/kg/12W-C
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Liver - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 112,297,1954
 
                            *** END OF RECORD ***