*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TL6490000 CHEMICAL NAME : Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride CAS REGISTRY NUMBER : 5897-18-7 LAST UPDATED : 199606 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C18-H22-N2.2Cl-H MOLECULAR WEIGHT : 339.34 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * Cyclizine dihydrochloride * 1-Diphenylmethyl-4-methylpiperazine dihydrochloride * Piperazine, 1-benzhydryl-4-methyl-, dihydrochloride *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 69 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 46,279,1957 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 11928 mg/kg/12W-C TOXIC EFFECTS : Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 112,297,1954 *** END OF RECORD ***