*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL6845000
CHEMICAL NAME           : 1-Piperazineethanol,
                          4-(4-amino-6-trifluoromethyl-2-s-triazinyl)-
CAS REGISTRY NUMBER     : 58892-43-6
LAST UPDATED            : 199106
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C10-H15-F3-N6-O
MOLECULAR WEIGHT        : 292.31
WISWESSER LINE NOTATION : T6N CN ENJ BZ DXFFF F- AT6N DNTJ D2Q
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4-(4-Amino-6-trifluoromethyl-2-s-triazinyl)-1-piperazineethanol
   * TR-10
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 820 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 26,559,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 465 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 96,223,1976
 
                            *** END OF RECORD ***