*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : TL3485000 CHEMICAL NAME : Piperazine, citrate (3:2) CAS REGISTRY NUMBER : 144-29-6 LAST UPDATED : 199706 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C12-H30-N6.C12-H16-O14 MOLECULAR WEIGHT : 642.76 WISWESSER LINE NOTATION : T6M DMTJ & 3 &622 &QV1XQVQ1VQ & 2 &621 COMPOUND DESCRIPTOR : Drug Human SYNONYMS/TRADE NAMES : * Antepar * Anthecole * Antoban * Arpezine * Ascarex Syrup * Bryrel * Exelmin * Exopin * Helmezine * Multifuge * Multifuge citrate * Nemadital * Oxucide * Parazine * Pin-Tega * Piperazine citrate * Piperazine Citrate Telra * Pipizan * Pipizan Citrate Syrup * Rhomex * Tasnon * Ta-Verm * Tripiperazine dicitrate * Vermago * Vermizine (elixir) *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 260 mg/kg/3D-I TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - coma Behavioral - headache REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,895,1967 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 150 mg/kg/5D TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - diplopia Behavioral - tremor Gastrointestinal - nausea or vomiting REFERENCE : JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 161,515,1956 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Human - infant DOSE/DURATION : 500 mg/kg/2D TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - coma REFERENCE : INPDAR Indian Pediatrics. (Dept. of Pediatrics, Safdarjang Hospital, New Delhi 110029, India) V.1- 1964- Volume(issue)/page/year: 18,71,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 11200 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,336,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 8500 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,336,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3548 mg/kg TOXIC EFFECTS : Behavioral - excitement Skin and Appendages - sweating REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 274,253,1985 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 175 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80482 No. of Facilities: 872 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3575 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80482 No. of Facilities: 12 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 146 (estimated) No. of Female Employees: 23 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***