*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL3485000
CHEMICAL NAME           : Piperazine, citrate (3:2)
CAS REGISTRY NUMBER     : 144-29-6
LAST UPDATED            : 199706
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C12-H30-N6.C12-H16-O14
MOLECULAR WEIGHT        : 642.76
WISWESSER LINE NOTATION : T6M DMTJ & 3 &622 &QV1XQVQ1VQ & 2 &621
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Antepar
   * Anthecole
   * Antoban
   * Arpezine
   * Ascarex Syrup
   * Bryrel
   * Exelmin
   * Exopin
   * Helmezine
   * Multifuge
   * Multifuge citrate
   * Nemadital
   * Oxucide
   * Parazine
   * Pin-Tega
   * Piperazine citrate
   * Piperazine Citrate Telra
   * Pipizan
   * Pipizan Citrate Syrup
   * Rhomex
   * Tasnon
   * Ta-Verm
   * Tripiperazine dicitrate
   * Vermago
   * Vermizine (elixir)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 260 mg/kg/3D-I
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - coma
   Behavioral - headache
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,895,1967
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 150 mg/kg/5D
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - diplopia
   Behavioral - tremor
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   161,515,1956
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 500 mg/kg/2D
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
REFERENCE :
   INPDAR Indian Pediatrics.  (Dept. of Pediatrics, Safdarjang Hospital, New
   Delhi 110029, India) V.1-    1964-  Volume(issue)/page/year: 18,71,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 6,336,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 6,336,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3548 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Skin and Appendages - sweating
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 274,253,1985
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 80482
       No. of Facilities: 872 (estimated)
       No. of Industries: 2
       No. of Occupations: 7
       No. of Employees: 3575 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 80482
       No. of Facilities: 12 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 146 (estimated)
       No. of Female Employees: 23 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***